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Table 3 Relationships between CAIX and HIF-1α & clinicopathological variables

From: Overexpression of carbonic anhydrase and HIF-1α in Wilms tumours

Characteristic No No (%) stained for CAIX p-value No (%) stained for HIF-1α p-value
Relapse/metastases      
   Present 8 4 > 0.99 6 0.49
   Absent 62 40 (65%)   59 (95%)  
Chemotherapy status      
   Pre-CT 22 16 (73%) 0.47 20 (91%) 0.29
   Post-CT 40 24 (60%)   39 (98%)  
Stage Post-CT      
1 14 9 (64%) 0.85 14 (100%)
2 13 7 (54%)   13 (100%)  
3/4/5 13 8 (62%)   12 (92%)  
Risk group Post-CT      
High-risk 5 2 0.37 5 > 0.99
Low/Intermediate risk 35 22 (63%)   34 (97%)  
Histological type Post-CT      
Blastemal 8 3 8
Epithelial/Stromal 10 9 (90%)   10 (100%)  
Mixed 16 8 (50%)   15 (94%)  
Regressive 6 4   6  
*Size (cm) Post-CT    > 0.99   0.45
≤9 22 13 (59%)   22 (100%)  
> 9 18 11 (61%)   17 (94%)  
**Weight (g) Post-CT      
≤299 20 7 (35%) 0.057 17 (85%) > 0.99
> 299 20 14 (70%)   17 (85%)  
  1. CT - chemotherapy, * size - 9 cm is the median size, **weight - 299 g is the median weight of total nephrectomy specimens. In 3 cases weight was unavailable, while 2 were partial nephrectomies.
  2. †expected frequencies too small to do χ2-test
  3. 8 WT samples obtained from metastatic sites in addition to their primary tumours. Repeated samples from the same patient were regarded as independent samples in these comparisons.