Overexpression of carbonic anhydrase and HIF-1α in Wilms tumours

BMC Cancer

Table 2 HIF-1α, CA IX, GLUT1 and VEGF expression in pre-chemotherapy WTs

Marker	Tumours +ve (%)	Level of expression (median)	Pattern of co-expression
CA IX	56	0-60 (5)	+	+	+	+	-	-	-	-	+	+	-	-	+	-	+
HIF-1α	94	0-80 (40)	+	+	+	-	+	-	-	-	+	-	+	+	-	+	-
GLUT1	100	30-80 (60)	+	+	-	+	+	+	-	-	-	-	+	-	+	-	-
VEGF	94	5-90 (10)	+	-	+	+	+	+	+	-	-	-	-	-	-	+	+
Co-expression^a			7	1	0	1	5	0	0	0	0	0	0	0	0	0	0
Co-localization^b			6	1	0	0	4	0	0	0	0	0	1	0	0	0	0

Table shows expression in pre-chemotherapy WT samples that were CA IX positive (n = 14).
^a number of positive cases showing specific staining of all four markers (+ or - sign in each line indicates positivity and negativity in respective staining in the same tumour)
^b number of positive cases showing specific staining of all four markers (+ or - sign in each line indicates positivity and negativity in respective staining in the same area of the same tumour)

ISSN: 1471-2407