|
time [hrs]
|
12
|
24
|
|---|
|
treatment
|
LY
|
PD
|
RA
|
LY+
|
PD+
|
RA+
|
LY
|
PD
|
RA
|
LY+
|
PD+
|
RA+
|
|---|
|
BHY
|
< 0.001
|
0.781
|
0.050
|
0.089
|
0.023
|
0.021
|
< 0.001
|
0.007
|
0.011
|
0.131
|
0.125
|
0.005
|
|
CAL
|
0.001
|
< 0.001
|
0.003
|
0.027
|
0.107
|
0.088
|
< 0.001
|
< 0.001
|
< 0.001
|
0.154
|
0.301
|
0.024
|
|
HN
|
< 0.001
|
< 0.001
|
< 0.001
|
0.002
|
0.041
|
0.014
|
< 0.001
|
< 0.001
|
< 0.001
|
0.001
|
0.003
|
< 0.001
|
- The p-values are shown for the effect of blocking in controls (tested hypotheses: βLY = 0, βPD = 0, βRA = 0) and for the interaction (+) with radiation (tested hypotheses: βrad.LY = 0, βrad.PD = 0, βrad.RA = 0, etc). All interaction coefficients were negative, indicating that the effect of radiation on migration was weaker after inhibition. (LY294002 (LY), PD98059 (PD), rapamycin (RA))
