Table 5 Hematologic and non-hematologic toxicity (NCI-CTC version 3.0)
Toxicity | NCI-CTC Grade (n = 32) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 2 | 3 | 4 | |||||||
No. | (%) | No. | (%) | No. | (%) | No. | (%) | No. | (%) | ||
Hematologic | |||||||||||
Leukocytopenia | 4 | (12.5) | 9 | (28.1) | 11 | (34.4) | 8 | (25.0) | 0 | (0.0) | |
Neutropenia | 5 | (15.6) | 3 | (9.4) | 7 | (21.9) | 10 | (31.3) | 7 | (21.9) | |
Anemia | 1 | (3.1) | 12 | (37.5) | 17 | (53.1) | 2 | (6.3) | 0 | (0.0) | |
Thrombocytopenia | 28 | (87.5) | 4 | (12.5) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |
Non-hematologic | |||||||||||
Neurology | Neuropathy | 18 | (56.3) | 8 | (25.0) | 5 | (15.6) | 1 | (3.1) | 0 | (0.0) |
GI | Stomatitis | 13 | (40.6) | 12 | (37.5) | 4 | (12.5) | 3 | (9.4) | 0 | (0.0) |
Anorexia | 10 | (31.3) | 17 | (53.1) | 5 | (15.6) | 0 | (0.0) | 0 | (0.0) | |
Nausea/Vomiting | 16 | (50.0) | 16 | (50.0) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |
Constipation | 23 | (71.9) | 6 | (18.8) | 3 | (9.4) | 0 | (0.0) | 0 | (0.0) | |
Diarrhea | 24 | (75.0) | 7 | (21.9) | 1 | (3.1) | 0 | (0.0 | 0 | (0.0) | |
Hepatic | AST↑ | 27 | (84.4) | 4 | (12.5) | 1 | (3.1) | 0 | (0.0) | 0 | (0.0) |
ALT↑ | 29 | (90.6) | 3 | (9.4) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |
Bilirubin↑ | 25 | (78.1) | 6 | (18.8) | 1 | (3.1) | 0 | (0.0) | 0 | (0.0) | |
Renal | Creatinine↑ | 23 | (71.9) | 8 | (25.0) | 1 | (3.1) | 0 | (0.0) | 0 | (0.0) |
Dermatology | Alopecia | 5 | (15.6) | 16 | (50.0) | 11 | (34.4) | 0 | (0.0) | 0 | (0.0) |
Rash | 25 | (78.1) | 5 | (15.6) | 2 | (6.3) | 0 | (0.0) | 0 | (0.0) | |
Itching | 27 | (84.4) | 5 | (15.6) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | |
Hyperpigmentation | 20 | (62.5) | 10 | (31.3) | 2 | (6.3) | 0 | (0.0) | 0 | (0.0) | |
Nail change | 24 | (75.0) | 3 | (9.4) | 4 | (12.5) | 1 | (3.1) | 0 | (0.0) | |
Hand-foot syndrome | 18 | (56.3) | 9 | (28.1) | 4 | (12.5) | 1 | (3.1) | 0 | (0.0) | |
Others | Asthenia | 8 | (25.0) | 16 | (50.0) | 6 | (18.8) | 2 | (6.3) | 0 | (0.0) |
Myalgia | 23 | (71.9) | 8 | (25.0) | 1 | (3.1) | 0 | (0.0) | 0 | (0.0) | |
Febrile neutropenia | 30 | (93.8) | 0 | (0.0) | 0 | (0.0) | 2 | (6.3) | 0 | (0.0) | |
Pneumonitis | 30 | (93.8) | 1 | (3.1) | 0 | (0.0) | 1 | (3.1) | 0 | (0.0) | |