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Table 4 Proteins detected with 2D-nanoLC-MS/MS in 14 pairs or more

From: Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study

  

Pairs*

Weighted ratio†

Random fixed

effects model

Protein Name

Function

n

Mean

95%CI

p-value

Vitronectin

 

16

1.06

0.99-1.13

.07

Transthyretin

 

15

0.98

0.88-1.09

.71

Alpha-1B-glycoprotein

 

20

1.03

0.99-1.07

.17

Alpha-2-macroglobulin

Proteinase inhibitor

20

0.94

0.88-1.00

.04

Afamin

Serum transport protein

17

1.10

1.02-1.18

.02

AMBP protein

 

18

1.04

0.97-1.12

.26

Apolipoprotein A-I

 

20

1.04

0.97-1.12

.25

Apolipoprotein A-II

 

20

0.98

0.91-1.06

.61

Apolipoprotein A-IV

 

20

1.05

0.95-1.18

.32

Apolipoprotein B-100

 

20

1.06

0.99-1.12

.08

Complement C3 (Fragment)

 

20

1.02

0.98-1.06

.34

Isoform 1 of Complement factor H

 

18

1.02

0.97-1.07

.39

Ceruloplasmin

Acute phase reactant

20

0.94

0.89-0.99

.03

Hemopexin

 

20

0.96

0.90-1.02

.17

Histidine-rich glycoprotein

 

20

0.96

0.89-1.04

.30

Inter-alpha trypsin inhibitor heavy chain H1

 

16

1.00

0.94-1.07

.89

Alpha-1-acid glycoprotein 2

 

16

1.00

0.93-1.08

.91

Inter-alpha (Globulin) inhibitor H2

 

18

0.96

0.89-1.04

.33

Orosomucoid 1

 

20

1.06

0.98-1.14

.16

Alpha-1-antichymotrypsin

 

19

1.00

0.92-1.08

.94

B-factor, properdin

 

18

0.99

0.94-1.05

.76

Plasminogen

 

18

0.98

0.90-1.07

.69

Alpha-2-HS-glycoprotein

 

18

1.00

0.94-1.07

.88

Beta-2-glycoprotein 1

 

18

0.99

0.92-1.05

.66

C4B1

 

16

0.99

0.93-1.05

.74

Prothrombin (Fragment)

 

16

0.98

0.88-1.10

.76

Apolipoprotein E

Lipid metabolism

16

1.13

1.01-1.26

.04

Apolipoprotein C-I

 

14

1.02

0.94-1.12

.57

13 kDa protein

 

14

1.03

0.92-1.16

.55

Isoform LMW of Kininogen-1

 

18

1.06

0.98-1.14

.13

Isoform 1 of inter-alpha trypsin inhibitor heavy chain H4

Acute phase reactant

16

1.08

1.03-1.14

<.01

Vitamin D-binding protein

 

20

1.03

0.99-1.07

.17

  1. 95%CI: 95% confidence interval; * Number of pairs in which a ratio could be determined and a EF could be calculated; † Ratio case/control
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BMC Cancer

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