Recipient Mice*
|
Number of mice
|
Number with tumor
|
p‡
|
---|
Rag2-/-
|
15
|
15
|
_
|
C57Bl/6
|
15
|
1
|
0.0001
|
UV-irradiated C57Bl/6†
|
15
|
2
|
0.0001
|
- * 2 × 106 tumor cells were injected into the subcutaneous space of the recipient mice. Tumor growth was monitored daily. Mice were sacrificed when the tumor volume exceeded 1 cm2.
- † 10 kJ/m2 UVB radiation, 3x per week for 12 weeks prior to tumor transplantation
- ‡ p values determined by Fisher's exact test comparing tumor growth in immune deficient Rag2-/- vs. growth in wild type or UV-irradiated wild type mice.