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Table 2 Pyrosequencing analysis of 20 matched samples: average methylation values of 51 CpGs in CpG island A of RASSF1A, of which 17 CpGs in the promoter and 34 CpGs in the first exon

From: Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

  Average methylation (%)
Cases*    
  Promoter First Exon CpG island A
N1 4 2 3
T1 2 4 3
N2 34 75 60
T2 20 11 14
N3 29 14 19
T3 37 19 25
N4 2 2 2
T4 23 8 13
N5 37 22 28
T5 59 56 57
N6 27 18 22
T6 29 10 17
N7 40 35 37
T7 53 52 52
N8 47 37 40
T8 77 46 57
N9 43 32 35
T9 46 29 35
N10 35 34 34
T10 49 72 64
N11 37 38 38
T11 38 43 41
N12 28 18 22
T12 42 66 57
N13 25 34 31
T13 67 65 66
N14 4 3 4
T14 49 30 37
N15 36 28 31
T15 50 37 41
N16 14 8 10
T16 10 9 9
N17 3 2 2
T17 3 5 4
N18 4 18 13
T18 32 7 16
N19 10 6 8
T19 25 37 33
N20 25 36 32
T20 43 80 67
  1. *N = normal pancreas, T = PET.