Table 1 Multivariate analysis of the Dicer mRNA in normal mucosa, gender, age, tumour site, stage and differentiation in relation to patient survival
From: Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients
Variables | n | Hazard Ratio | 95% CI | P |
|---|---|---|---|---|
Dicer mRNA | 0.0006 | |||
Low | 106 | 1.000 | - | |
High | 37 | 3.682 | 1.749 - 7.750 | |
Gender | 0.462 | |||
Male | 91 | 1.000 | - | |
Female | 52 | 0.744 | 0.337 - 1.639 | |
Age (years) | 0.052 | |||
≤ 72 | 60 | 1.000 | - | |
> 72 | 83 | 2.082 | 0.993 - 4.363 | |
Tumour site | 0.072 | |||
Colon | 88 | 1.000 | - | |
Rectum | 55 | 0.478 | 0.214 - 1.069 | |
Stage | < 0.0001 | |||
I | 20 | 1.000 | - | |
II | 75 | 0.903 | 0.189 - 4.317 | |
III | 33 | 3.651 | 0.793 - 16.803 | |
IV | 15 | 16.726 | 3.335 - 83.871 | |
Differentiation | 0.415 | |||
Better | 103 | 1.000 | - | |
Worse | 40 | 1.398 | 0.625 - 3.130 |