Table 1 Clinicopathologic and molecular characteristics of colorectal cancers according to the CIMP status
| Â | CIMP-low/negative (n = 211) | CIMP-high (n = 34) | Pvalue |
|---|---|---|---|
Age (yrs) | Â | Â | 0.388 |
   Mean ± SD | 59.7 ± 11.9 | 61.6 ± 11.9 |  |
   Median (range) | 62.0 (29 - 83) | 63.5 (33 - 82) |  |
Gender (%) | Â | Â | 0.752 |
   Male | 118 (55.9) | 20 (58.8) |  |
   Female | 93 (44.1) | 14 (41.2) |  |
Tumor site (%) | Â | Â | < 0.001 |
   Proximal | 64 (30.3) | 23 (67.6) |  |
   Distal | 147 (69.7) | 11 (32.4) |  |
Lymph node metastasis (%) | Â | 0.770 | |
   Absent | 106 (50.2) | 18 (52.9) |  |
   Present | 105 (49.8) | 16 (47.1) |  |
AJCC stage (%) | Â | Â | 0.548 |
   I/II | 100 (47.4) | 18 (52.9) |  |
   III/IV | 111 (52.6) | 16 (47.1) |  |
Differentiation (%) | Â | Â | < 0.001 |
   Well/Moderate | 191 (90.5) | 21 (61.8) |  |
   Poor/Mucinous | 20 (9.5) | 13 (38.2) |  |
Mucinous histology (%) | Â | Â | 0.045... |
   Absent | 202 (95.7) | 28 (82.4) |  |
   Present | 9 (4.3) | 6 (17.6) |  |
BRAF (%) | Â | Â | < 0.001 |
   Wild type | 209 (99.1) | 25 (73.5) |  |
   Mutation | 2 (0.9) | 9 (26.5) |  |
KRAS (%) | Â | Â | 0.894 |
   Wild type | 139 (65.9) | 22 (64.7) |  |
   Mutation | 72 (34.1) | 12 (35.3) |  |
MGMT methylation (%) | Â | Â | < 0.001 |
   Absent | 153 (72.5) | 12 (35.3) |  |
   Present | 58 (27.5) | 22 (64.7) |  |
MSI status (%) | Â | Â | < 0.001 |
   MSS/MSI-low | 183 (86.7) | 13 (38.2) |  |
   MSI-high | 28 (13.3) | 21 (61.8) |  |