Table 2 SNPassoc results for previously identified and mucin SNPs in EPICOLON cohorts.
EPICOLON stages 1+2 (1,416 CRC cases and 1,424 controls) | ||||||||
|---|---|---|---|---|---|---|---|---|
ADH1C | ||||||||
rs698 | Controls | % | Cases | % | OR | lower | upper | P-value |
Codominant | ||||||||
A/A | 629 | 46.1 | 616 | 44.2 | 1.00 | 0.13565 | ||
A/G | 610 | 44.7 | 620 | 44.4 | 1.04 | 0.89 | 1.22 | |
G/G | 125 | 9.2 | 159 | 11.4 | 1.30 | 1.00 | 1.69 | |
Dominant | ||||||||
A/A | 629 | 46.1 | 616 | 44.2 | 1.00 | 0.29181 | ||
A/G-G/G | 735 | 53.9 | 779 | 55.8 | 1.08 | 0.93 | 1.26 | |
Recessive | ||||||||
A/A-A/G | 1239 | 90.8 | 1236 | 88.6 | 1.00 | 0.05243 | ||
G/G | 125 | 9.2 | 159 | 11.4 | 1.28 | 1.00 | 1.63 | |
Log-Additive | ||||||||
0, 1, 2 | 1364 | 49.4 | 1395 | 50.6 | 1.10 | 0.98 | 1.24 | 0.09043 |
IL6 | ||||||||
rs1800795 | Controls | % | Cases | % | OR | lower | upper | P-value |
Codominant | ||||||||
G/G | 593 | 42.7 | 586 | 41.7 | 1.00 | 0.7950 | ||
G/C | 623 | 44.9 | 635 | 45.2 | 1.03 | 0.88 | 1.21 | |
C/C | 172 | 12.4 | 184 | 13.1 | 1.08 | 0.85 | 1.37 | |
Dominant | ||||||||
G/G | 593 | 42.7 | 586 | 41.7 | 1.00 | 0.5862 | ||
G/C-C/C | 795 | 57.3 | 819 | 58.3 | 1.04 | 0.90 | 1.21 | |
Recessive | ||||||||
G/G-G/C | 1216 | 87.6 | 1221 | 86.9 | 1.00 | 0.5763 | ||
C/C | 172 | 12.4 | 184 | 13.1 | 1.07 | 0.85 | 1.33 | |
log-Additive | ||||||||
0, 1, 2 | 1388 | 49.7 | 1405 | 50.3 | 1.04 | 0.93 | 1.16 | 0.5034 |
ARL11 | ||||||||
rs3803185 | Controls | % | Cases | % | OR | lower | upper | P-value |
Codominant | ||||||||
A/A | 359 | 26.9 | 301 | 23.7 | 1.00 | 0.12263 | ||
A/G | 686 | 51.4 | 666 | 52.4 | 1.15 | 0.95 | 1.39 | |
G/G | 289 | 21.7 | 304 | 23.9 | 1.26 | 1.01 | 1.57 | |
Dominant | ||||||||
A/A | 359 | 26.9 | 301 | 23.7 | 1.00 | 0.06417 | ||
A/G-G/G | 975 | 73.1 | 970 | 76.3 | 1.18 | 0.99 | 1.41 | |
Recessive | ||||||||
A/A-A/G | 1045 | 78.3 | 967 | 76.1 | 1.00 | 0.15480 | ||
G/G | 289 | 21.7 | 304 | 23.9 | 1.14 | 0.95 | 1.37 | |
log-Additive | ||||||||
0, 1, 2 | 1334 | 51.2 | 1271 | 48.8 | 1.12 | 1.00 | 1.25 | 0.04338 |
GALNTL2 | ||||||||
rs2102302 | Controls | % | Cases | % | OR | lower | upper | P-value |
Codominant | ||||||||
A/A | 579 | 42.1 | 538 | 39.0 | 1.00 | 0.16056 | ||
A/G | 607 | 44.1 | 624 | 45.3 | 1.11 | 0.94 | 1.30 | |
G/G | 189 | 13.7 | 217 | 15.7 | 1.23 | 0.98 | 1.55 | |
Dominant | ||||||||
A/A | 579 | 42.1 | 538 | 39.0 | 1.00 | 0.0971 | ||
A/G-G/G | 796 | 57.9 | 841 | 61.0 | 1.14 | 0.98 | 1.32 | |
Recessive | ||||||||
A/A-A/G | 1186 | 86.3 | 1162 | 84.3 | 1.00 | 0.14317 | ||
G/G | 189 | 13.7 | 217 | 15.7 | 1.17 | 0.95 | 1.45 | |
log-Additive | ||||||||
0, 1, 2 | 1375 | 49.9 | 1379 | 50.1 | 1.11 | 1.00 | 1.24 | 0.0558 |