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Figure 3 | BMC Cancer

Figure 3

From: A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

Figure 3

(A) P276 specifically inhibits VEGF mRNA expression under hypoxia in a dose-dependent manner in PC-3 cells. However, HIF-1α mRNA levels remained unchanged. (B) Inhibition of HIF-1α and VEGF expression in PC-3 and DU145 prostate cancer cells by P3155. Cells were treated with P3155 (3 μM) for 8 h at 37°C and stained with mouse antibody against HIF-1α and rabbit antibody against VEGF. Reduced coexpression of HIF-1α and VEGF was observed.

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BMC Cancer

ISSN: 1471-2407

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