Kinetic Targeting of pegylated liposomal Doxorubicin: a new Approach to Reduce Toxicity during Chemotherapy (CARL-trial)

Table 3 Elimination of plasma lipids and proteins

Plasma component	plasma level (prior to plasmapheresis)	elimination [%]
Lipids
Total cholesterol	193 ± 33 [mg/dl]	46 ± 8
LDL-cholesterol	104 ± 27 [mg/dl]	59 ± 10
HDL-cholesterol	57 ± 22 [mg/dl]	10 ± 8
Proteins
Total protein	6,7 ± 0,3 [g/dl]	16 ± 3
Albumin	4,2 ± 0,2 [g/dl]	13 ± 4
Transferrin	233 ± 30 [ng/dl]	12 ± 4
Ferritin	152 ± 115 [ng/dl]	22 ± 7
IgG	848 ± 144 [mg/dl]	18 ± 5

Plasma levels were measured by standard clinical chemistry methods immediately prior and past plasmapheresis. Fasting was not required prior to plasmapheresis, so total cholesterol, LDL-cholesterol and HDL-cholesterol could not be accurately estimated in all cycles (n = 32-57). All values are mean ± SD.

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