Figure 2From: Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas Schematic illustration of mechanism of action of PTGS1. PTGS1 induces PGE2-production. PGE2 increases the expression of aromatase (CYP19A1) which in turn converts androgens to estrogens in adipose tissue. 17βHSD1 = 17β-hydroxysteroid dehydrogenase.Back to article page