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Table 1 Leptin and VEGF enhance ES formation by HUVEC.

From: Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

Conditions

ES (%)

Untreated

100.0

Leptin

178.0 ± 3.0

Leptin + Aca1 10 nM

90.0 ± 1.0

Leptin + Aca1 25 nM

79.0 ± 6.5

Leptin + Aca1 50 nM

72.0 ± 32.5

Aca1 10 nM

103.5 ± 12.0

Aca1 25 nM

90.0 ± 1.0

Aca1 50 nM

68.0 ± 4.0

VEGF

160.0 ± 13.0

VEGF + SU1498 1 μM

121.0 ± 30.0

VEGF + SU1498 5 μM

98.0 ± 14.5

VEGF + SU1498 10 μM

73.0 ± 6.0

SU1498 1 μM

100.5 ± 23.0

SU1498 5 μM

91.0 ± 1.4

SU1498 10 μM

60.0 ± 10.0

  1. ObR and VEGFR inhibitors counteract this effect.
  2. Number of ES after treatment with 100 ng/mL leptin and/or Aca1Free 10, 25 and 50 nM or with 50 ng/mL VEGF and/or SU1498 1, 5 and 10 μM was scored as described in Materials and Methods. Untreated cells were taken as control (100%). Tube-like formation assay was performed for 8 h in VCBM. Means ± SD are shown.