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Table 2 Comparisons of clinical and tumor characteristics by molecular subtypes of breast cancer, the Shanghai Breast Cancer Survival Study.

From: Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study

Covariables Levels Luminal A Luminal B HER2 Triple-negative HER2 borderline P value
   N = 1355 N = 467 N = 382 N = 360 N = 227  
   No. (%) No. (%) No. (%) No. (%) No. (%)  
Mean age at diagnosis*   54.1(10.2) 52.3 (9.3) 53.4 (9.7) 53.5 (10.7) 53.1 (9.9) 0.03
Age at diagnosis        0.02
  <30 3 (0.22) 2 (0.43) 1 (0.26) 4 (1.11) 1 (0.44)  
  30-39 47 (3.47) 21 (4.50) 16 (4.19) 22 (6.11) 9 (3.96)  
  40-49 556 (41.03) 201 (43.04) 138 (36.13) 134 (37.22) 99 (43.61)  
  50-59 364 (26.86) 148 (31.69) 125 (32.72) 97 (26.94) 60 (26.43)  
  60-69 230 (16.97) 63 (13.49) 70 (18.32) 67 (18.61) 39 (17.18)  
  ≥70 155 (11.44) 32 (6.85) 32 (8.38) 36 (10.00) 19 (8.37)  
Pre-menopausal   661 (48.78) 239 (51.18) 167 (43.72) 174 (48.33) 114 (50.22) 0.27
Family history of breast cancer   61 (4.50) 21 (4.50) 17 (4.45) 28 (7.78) 17 (7.49) 0.048
TNM stage 0 32 (2.36) 11 (2.36) 8 (2.09) 7 (1.94) 5 (2.20) <0.01
  I 473 (34.91) 124 (26.55) 91 (23.82) 98 (27.22) 85 (37.44)  
  IIa 452 (33.36) 165 (35.33) 135 (35.34) 122 (33.89) 71 (31.28)  
  IIb 240 (17.71) 98 (20.99) 88 (23.04) 76 (21.11) 47 (20.70)  
  III-IV 109 (8.04) 55 (11.78) 51 (13.35) 42 (11.67) 15 (6.61)  
Tumor size, cm *   2.80 (1.91) 3.31 (3.03) 3.34 (2.26) 3.14 (1.57) 2.82 (1.73) <0.01
Histologic grade I 306 (22.58) 31 (6.64) 17 (4.45) 48 (13.33) 36 (15.86) <0.01
  II 736 (54.32) 217 (46.47) 140 (36.65) 106 (29.44) 113 (49.78)  
  III 219 (16.16) 159 (34.05) 190 (49.74) 175 (48.61) 60 (26.43)  
Histologic type Noninvasive** 41 (3.03) 20 (4.28) 18 (4.71) 10 (2.78) 7 (3.08) <0.01
  ILC NOS 142 (10.48) 23 (4.93) 8 (2.09) 18 (5.00) 24 (10.57)  
  IDC NOS 834 (61.55) 361 (77.30) 314 (82.20) 253 (70.28) 162 (71.37)  
  Special types 318 (23.47) 60 (12.85) 39 (10.21) 76 (21.11) 34 (14.98)  
  1. * Number presented as mean (standard deviation)
  2. **Including DCIS and LCIS.