Figure 8

CD44st and hyaluronan interaction leads to an increase in MCF-7/CD44st invasion capabilities. The invasive capability of the tumor cells was assayed in the presence (+) and absence (-) of HA (100 μg/ml) for 24 h with transwell pretreated filters. Cells in the pretreatment with CD44 blocking antibody groups were pretreated with anti-CD44 (20 μg/ml) for 3 h, and then treated with HA (100 μg/ml) for 24 h. ● P > 0.05, *P < 0.05.