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TIC
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time-intensity curve
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A curve to describe the signal intensity of contrast media in a region of interest changes over time when a series of ultrasonograms are analysed by specific software offline
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ROI
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region of interest
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A circle drawn in the interested region for generating the time-intensity curve. In this study, one ROI took the tumor region as a whole, the other one, "hotspot", was located in the highest enhanced area on contrast-enhanced ultrasonography, which were determined by the two sonography investigators
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ISI
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increased signal intensity
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The difference between baseline to the maximum increase in signal intensity in a region of interest
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RSI
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rate of signal increase
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The rate of signal enhancement from baseline to initial peak in a region of interest
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RWO
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rate of washout of 50% of contrast material
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The rate of signal intensity reduced to 50% of initial peak of contrast material in a region of interest
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MTT
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mean transit time
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Average persistence of a contrast material in a region of interest
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AUC
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area under the curve
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Integral calculus of the area under time-intensity curve, which reflects the total perfusion of a region of interest
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BF
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blood flow coefficient
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BF = AUC/MTT/2
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