Table 2 Relationship between mutagen sensitivity and polymorphisms in unrelated subjects (n = 110)

BRCA1

n = 44

%

n = 66

%

E1038R

Co-Dominant

TT

20

18.2%

23

20.9%

1.00

CT

18

16.4%

32

29.1%

1.08

0.45 - 2.64

CC

6

5.5%

11

10.0%

1.07

0.32 - 3.60

0.46

Dominant

CC/CT

24

21.8%

43

39.1%

1.60

0.47 - 2.47

0.34

Log-Additive

0.64 - 1.94

0.70

D693N

Dominant

CC

41

37.3%

57

51.8%

1.00

CT

1

0.9%

9

8.2%

6.03

0.69 - 52.02

0.10

Q356R

Dominant

TT

32

29.1%

56

50.9%

1.00

CT

11

10.0%

9

8.2%

0.57

0.20 - 1.60

0.28

Rad51

5' UTR 135G>C

Dominant

GG

36

35.0%

35

34.0%

1.00

CC/CG

7

6.8%

25

24.3%

3.64

1.38 - 9.54

0.03