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Table 2 Relationship between mutagen sensitivity and polymorphisms in unrelated subjects (n = 110)

From: Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk

   Genetic Model Genotype Low   High   OR* 95% CI p
BRCA1     n = 44 % n = 66 %    
  E1038R Co-Dominant TT 20 18.2% 23 20.9% 1.00   
    CT 18 16.4% 32 29.1% 1.08 0.45 - 2.64  
    CC 6 5.5% 11 10.0% 1.07 0.32 - 3.60 0.46
   Dominant CC/CT 24 21.8% 43 39.1% 1.60 0.47 - 2.47 0.34
   Log-Additive        0.64 - 1.94 0.70
  D693N Dominant CC 41 37.3% 57 51.8% 1.00   
    CT 1 0.9% 9 8.2% 6.03 0.69 - 52.02 0.10
  Q356R Dominant TT 32 29.1% 56 50.9% 1.00   
    CT 11 10.0% 9 8.2% 0.57 0.20 - 1.60 0.28
Rad51 5' UTR 135G>C          
   Dominant GG 36 35.0% 35 34.0% 1.00   
    CC/CG 7 6.8% 25 24.3% 3.64 1.38 - 9.54 0.03
  1. *Adjusted for age