Figure 6

Relationship between MR-1 expression levels and cell apoptosis. (A) The degree of apoptosis in SKOV3 cells treated by the anti-tumor drugs, paclitaxel and carboplatin, is shown (apoptotic cells appear as bright green spots, some of which are highlighted with arrows). Upper panel: a-d show SKOV3 cells treated for 48 h with 0, 12.5, 25, and 50 nmol/L paclitaxel. Lower panel: e-h show SKOV3 cells treated for 48 h with 0, 40, 80 and 160 mg/L carboplatin. (B, C) The rate of apoptosis was associated with MR-1 gene and protein expression levels. Representative example from three independent experiments is shown. **P < 0.05; ***P < 0.01 compared with the untreated group (one-way ANOVA).