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Figure 5 | BMC Cancer

Figure 5

From: Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFcchimeric protein targeting tissue factor

Figure 5

Cytotoxicity experiments adding human serum to hI-con1 (30 μg/ml) against one representative primary cervical cancer cell line overexpressing TF (i.e., CVX-7 ARK-7: effectors to target ratio 50:1 and 25:1). Cervical cancer cells were challenged by diluted (1:2) serum (with or without heat inactivation) added in the presence of the effector cells and hI-con1 in standard 5-h 51Cr release assays. Addition of treated or untreated human serum (diluted 1:2) to PBL in the presence of hI-con1 did not significantly change hI-con1-mediated cytotoxicity against CVX-7 ARK-7 (p = 0.597).

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BMC Cancer

ISSN: 1471-2407

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