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Table 3 PLCE1 haplotype and risk of SCCHN arising at non-oropharyngeal sites

From: Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

 

Haplotype frequencies

   

PLCE1haplotypes a

Cases (N = 1,068)

Controls (N = 2,134)

Crude OR (95% CI)

Adjusted OR b(95% CI)

P b

 

N

%

N

%

   

TAA

572

53.6

1131

53.0

1.00

1.00

 

GAA

128

12.0

318

14.9

0.80 (0.63-1.00)

0.72 (0.56-0.92)

0.008

TGA

119

11.1

198

9.3

1.19 (0.93-1.52)

1.31 (1.00-1.72)

0.049

GGG

87

8.1

179

8.4

0.96 (0.73-1.27)

0.96 (0.71-1.29)

0.771

TGG

96

9.0

170

8.0

1.12 (0.85-1.46)

1.10 (0.82-1.46)

0.528

GGA

66

6.2

138

6.5

0.95 (0.69-1.29)

0.85 (0.61-1.18)

0.334

  1. a The alleles of haplotypes were arrayed as the location of the SNPs in PLCE1 stand from 5' to 3' (e.g. TAA denotes Trs11599672Ars2274223Ars3203713).
  2. b Adjusted for age, gender, smoking and alcohol status in logistic models.
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BMC Cancer

ISSN: 1471-2407

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