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Table 2 Logistic regression analysis for associations between PLCE1 variant genotypes and SCCHN risk

From: Association between novel PLCE1variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck

Locus

Genotype

Controls (%)

Overall (N = 1,098)

Oropharynx (N = 559)

Non-oropharynx (N = 539)

  

(N = 1,090)

Cases (%)

OR (95%CI)a

Cases (%)

OR (95%CI)a

Cases (%)

OR (95%CI)a

PLCE1 rs2274223

        
 

AA

504 (46.3)

477 (43.5)

1.00

253 (45.3)

1.00

224 (41.6)

1.00

 

AG

474 (43.5)

506 (46.1)

1.14 (0.95-1.38)

248 (44.4)

1.09 (0.87-1.36)

258 (48.0)

1.29 (1.01-1.64)

 

GG

111 (10.2)

114 (10.4)

1.20 (0.88-1.62)

58 (10.3)

1.15 (0.80-1.64)

56 (10.4)

1.38 (0.93-2.06)

 

AG/GG

585 (53.7)

620 (56.5)

1.15 (0.97-1.38)

306 (54.7)

1.10 (0.89-1.36)

314 (58.4)

1.30 (1.03-1.64)

 

G allele

0.320

0.335

     

PLCE1 rs3203713

        
 

AA

759 (70.0)

753 (68.8)

1.00

391 (70.1)

1.00

362 (67.4)

1.00

 

AG

298 (27.5)

311 (28.4)

1.07 (0.88-1.31)

146 (26.2)

0.98 (0.77-1.25)

165 (30.7)

1.27 (0.99-1.64)

 

GG

27 (2.5)

31 (2.8)

1.28 (0.74-2.21)

21 (3.7)

1.74 (0.96-3.16)

10 (1.9)

0.80 (0.36-1.79)

 

AG/GG

325 (30.0)

342 (31.2)

1.09 (0.90-1.32)

167 (29.9)

1.04 (0.83-1.31)

175 (32.6)

1.23 (0.96-1.58)

 

G allele

0.162

0.170

     

PLCE1 rs11599672

        
 

TT

519 (48.3)

554 (50.8)

1.00

270 (48.8)

1.00

284 (52.9)

1.00

 

TG

473 (44.0)

469 (43.0)

0.94 (0.78-1.13)

246 (44.5)

1.03 (0.83-1.28)

223 (41.5)

0.81 (0.64-1.02)

 

GG

82 (7.7)

67 (6.2)

0.72 (0.50-1.03)

37 (6.7)

0.89 (0.58-1.37)

30 (5.6)

0.54 (0.34-0.86)

 

TG/GG

555 (51.7)

536 (49.2)

0.91 (0.76-1.08)

283 (51.2)

1.01 (0.82-1.25)

253 (47.1)

0.76 (0.61-0.95)

 

G allele

0.297

0.277

     

Combined effect of risk alleles b

        

Trichotomy

0-1

263 (24.6)

235 (21.6)

1.00

124 (22.5)

1.00

111 (20.8)

1.00

 

2-3

607 (56.9)

630 (58.0)

1.20 (0.97-1.50)

320 (58.0)

1.14 (0.88-1.48)

310 (58.1)

1.29 (0.97-1.73)

 

4-6

197 (18.5)

221 (20.4)

1.31 (1.00-1.73)

108 (19.6)

1.23 (0.89-1.70)

113 (21.2)

1.54 (1.08-2.20)

    

P trend = 0.046

 

P trend = 0.210

 

P trend = 0.017

Dichotomy

0-1

263 (24.6)

235 (21.6)

1.00

124 (22.5)

1.00

111 (20.8)

1.00

 

2-6

804 (75.4)

851 (78.4)

1.23 (1.00-1.52)

428 (77.5)

1.16 (0.90-1.49)

423 (79.2)

1.35 (1.03-1.78)

  1. a Adjusted for age, sex, smoking and alcohol status. The SNP calling rates were all >98% with 2 samples failed in rs2274223, 9 samples in rs3203713 and 24 samples in rs11599672.
  2. b The risk alleles: rs2274223G, rs3203713G and rs11599672T.
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