Table 8 Significant alterations in expression of transcription factors and cell signaling factors in normal colon mucosa from patients with tumors of high intrinsic COX-2 expression
Gene | Product | FC 1.5 | FC 2.0 | FC 3.0 |
|---|---|---|---|---|
PTGS2 | COX-2 | ↑ | ↑ | ↑ |
Transcription | ||||
ATF3 | ATF3/AP1 | ↑ | - | - |
CEBPD | C/EBP-δ | ↑ | ↑ | - |
CREB1 | CREB | ↑ | - | - |
FOSB | Fos-B/AP1 | ↑ | ↑ | - |
DNAJC12 | JDP1 | ↑ | - | - |
NFATC1 | NFATc1/NFAT2 | ↓ | - | - |
PPARG | PPARγ | ↓ | - | - |
BATF | B-ATF | ↓ | - | - |
External cell factors | ||||
IL1B | IL1b | ↑ | ↑ | ↑ |
IL6 | IL6 | ↑ | ↑ | ↑ |
NOS2A | iNOS | ↑ | ↑ | ↑ |