Skip to main content

Table 7 Significant alterations in expression of previously reported important external cell signaling factors and enzymes in tumors of high intrinsic COX-2 expression

From: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Gene

Product

FC 1.5

FC 2.0

FC 3.0

Referencea

DNMT1

DNA MTase 1

-

-

-

[26]

DNMT3A

DNA MTase 3A

↑

↑

-

[26]

DNMT3B

DNA MTase 3B

-

-

-

[26]

MDM2

hdm2

-

-

-

[30]

HPGD

HPGD

-

-

-

[1]

HNRPD

HuR

-

-

-

[31]

IL1B

IL1b

↑

↑

-

[32, 33]

IL6

IL6

↑

↑

↑

[34]

IL6R

IL6 receptor

↑

-

-

[34]

NOS2A

iNOS

-

-

-

[13]

MAPK14

p38 MAPK

-

-

-

[35]

PTGES

mPGES-1

-

-

-

[1]

PRKCB1

Protein kinas Cβ1

↑

↑

↑

[12]

RALA

Ras family (oncogene)

-

-

-

[12]

RASA4

Ras p21 protein activator

-

-

-

[12]

RASSF1

Ras ass. (tumor supr.)

-

-

-

[12]

RIN2

Ras and Rab interact. 2

-

-

-

[12]

TINP1

TGF-β

-

-

-

[13]

TNF

TNF-α

↑

-

-

[13]

  1. ↑ increased expression
  2. ↓ decreased expression
  3. FC is log2 fold change
  4. a published report with emphasis on the current factors
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us