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Table 7 Significant alterations in expression of previously reported important external cell signaling factors and enzymes in tumors of high intrinsic COX-2 expression

From: COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Gene Product FC 1.5 FC 2.0 FC 3.0 Referencea
DNMT1 DNA MTase 1 - - - [26]
DNMT3A DNA MTase 3A - [26]
DNMT3B DNA MTase 3B - - - [26]
MDM2 hdm2 - - - [30]
HPGD HPGD - - - [1]
HNRPD HuR - - - [31]
IL1B IL1b - [32, 33]
IL6 IL6 [34]
IL6R IL6 receptor - - [34]
NOS2A iNOS - - - [13]
MAPK14 p38 MAPK - - - [35]
PTGES mPGES-1 - - - [1]
PRKCB1 Protein kinas Cβ1 [12]
RALA Ras family (oncogene) - - - [12]
RASA4 Ras p21 protein activator - - - [12]
RASSF1 Ras ass. (tumor supr.) - - - [12]
RIN2 Ras and Rab interact. 2 - - - [12]
TINP1 TGF-β - - - [13]
TNF TNF-α - - [13]
  1. increased expression
  2. decreased expression
  3. FC is log2 fold change
  4. a published report with emphasis on the current factors