Table 4 Genes listed according to the magnitude of most altered expression in tumor tissue of high intrinsic COX-2 expression

Unknown

156

unknown

W60781

Myosin

107

Muscle, heavy polypeptide 2

MYH2 (4620)

Desmin

49

Muscle filament

DES (1674)

Creatine kinase

46

Muscle, energy homeostasis, serum marker for myocardial infarction

CKM (1158)

Troponin T type 3

41

Skeletal

TNNT3 (7140)

Actin α, cardiac

37

Muscle, contractile, cell motility

ACTC1 (70)

Actin α1, skeletal

35

Cell motility, structure and integrity

ACTA1 (58)

Synaptopodin 2

28

Cell-shape regulation, homolog with Myopodin (a tumor suppressor; inhibits growth and metastasis)

SYNPO2 (171024)

Nebulin

25

Cytoskeletal matrix

NEB (4703)

Calponin

23

Differentiation marker, reduced in tumor vessels associated with tumor progression

CNN1 (1264)

Growth diff. factor 10

28

Regulation of cell growth and differentiation

GDF10 (2662)

Unc-13 homolog A

19

diacylglycerol and phorbol ester receptors, essential role in synaptic vesicle priming

UNC13A (23025)

LOC553137

16

miscRNA, unknown function

LOC553137 (553137)

Melanoma antigen family B, 2

14

Tumor-associated antigen, expressed only in testis and tumors, regulated by demethylation

MAGEB2 (4113)

Chondrosarcoma associated gene 1

13

Tumor antigen, expressed in testis and in chondrosarcomas

CSAG1 (158511)

Folate receptor 1

13

Involvement in cancer prognosis

FOLR1 (2348)

Renin

13

Blood pressure and electrolyte balance

REN (5972)

Small proline-rich protein 3

12

Epithelial homeostatis, aberrant expression contribute to tumorigenesis of esophageal squamous cell carcinoma

SPRR3 (6707)

Heat shock 27kDa protein 3

12

Muscle

HSPB3 (8988)

Chromogranin B

11

Precursor for biological active peptides, involved early in breast cancer

CHGB (1114)