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Table 2 Univariate Odds Ratios (OR's) for associations with advanced stage at diagnosis of non-small cell lung cancer

From: Lung cancer stage at diagnosis: Individual associations in the prospective VITamins and lifestyle (VITAL) cohort

Variable

Advanced Stage

Regional/Distant/Unknown

 

OR

95% CI

Demographics

Age (per year)

1.00

(0.98 - 1.03)

Women

0.68

(0.46 - 1.01)

Non-White Race/Ethnicity

1.24

(0.50 - 3.07)

Smoking

Years of Smoking (10 year increments)*

1.07

(0.93 - 1.23)

Pack Years (10 year increments)*

1.05

(0.98 - 1.13)

Smoking Status

  

   Never smoker

Ref

 

   Current smoker

1.81

(0.90 - 3.63)

   Former, Quit <10 yr

2.56

(1.17 - 5.60)

   Former, Quit ≥10 yr

1.82

(0.93 - 3.55)

Socioeconomic

College Graduate or Higher

1.66

(1.00 - 2.76)

Income >$40,000/year

1.04

(0.67 - 1.62)

Currently Married or with Partner

0.77

(0.49 - 1.21)

Medical History

COPD

0.81

(0.48 - 1.35)

History of Cancer

1.00

(0.62 - 1.60)

Family History Lung Cancer**

0.79

(0.49 - 1.26)

Comorbid Disease*** (1 or more)

1.03

(0.69 - 1.52)

Exercise (Highest Quartile)****

1.15

(0.69 - 1.93)

BMI Category (kg/m 2 )

   Normal (18.5 - 24.9)

Ref

 

   Underweight (<18.5)

0.50

(0.14 - 1.74)

   Overweight (25 - 29.9)

0.87

(0.55 - 1.37)

   Obese (≥30)

0.97

(0.55 - 1.72)

   Missing

0.78

(0.34 - 1.78)

Screening Activities

Sigmoidoscopy/Colonoscopy

0.65

(0.43 - 0.99)

PSA (men only)

0.93

(0.50 - 1.73)

Mammogram (women only)

1.47

(0.61 - 3.59)

Screening (at least one screening study)

0.81

(0.43 - 1.53)

  1. *among current or former smokers
  2. ** ≥1 1st degree relative with lung cancer
  3. ***See definition in text
  4. **** usual MET hours per week for each activity averaged over the previous 10 years