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Table 2 P53 targets differentially expressed in melanoma cells

From: P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

No. Accession No. Gene Symbol Gene Name Fold change p-value
Apoptosis     
Induction of apoptosis     
1 NM_138765.2 BAX BCL2-associated X protein, transcript variant sigma -4.19 0.0062
2 NM_004324.3 BAX1 BCL2-associated X protein, transcript variant beta -4.67 0.0059
3 NM_001225.3 CASP4 Caspase 4, transcript variant alpha -2.32 0.0027
4 NM_001226.3 CASP61 Caspase 6, transcript variant alpha 3.17 0.0401
5 NM_021202.1 TP53INP2 Tumor protein p53 inducible nuclear protein 2 -3.02 0.0034
6 NM_147184.1 TP53I3/PIG3 Tumor protein p53 inducible protein 3, transcript variant 2 -3.67 0.0031
Inhibition of apoptosis     
7 NM_138578.1 BCL2L11 B-cell CLL/lymphoma 2-like 1, transcript variant 1 -2.95 0.0124
8 NM_003840.3 TNFRSF10D1 Tumor necrosis factor receptor superfamily, member 10d -33.80 0.0005
Cell cycle, proliferation and differentiation   
9 NM_001012271.1 BIRC5 Baculoviral IAP repeat-containing 5 (Survivin), transcript variant 3 4.60 0.0024
   BIRC5   12.61 1.8E-05
10 NM_031966.2 CCNB1 Cyclin B1 18.17 0.0005
11 NM_001759.2 CCND21 Cyclin D2 -75.73 0.0427
12 NM_001238.1 CCNE11 Cyclin E1, transcript variant 1 2.34 0.0310
13 NM_057735.1 CCNE2 Cyclin E2, transcript variant 2 9.33 0.0198
14 NM_001786.2 CDC2/CDK1 Cell division cycle 2, transcript variant 1 6.32 0.0127
15 NM_001790.3 CDC25C Cell division cycle 25 homolog C, transcript variant 1 17.05 0.0020
16 NM_001790.3 CDC25C Cell division cycle 25 homolog C, transcript variant 1 15.26 0.0001
17 NM_022809.2 CDC25C Cell division cycle 25 homolog C, transcript variant 2 13.39 0.0011
   CDC25C   18.21 0.0004
18 NM_058197.3 CDKN2A1 Cyclin-dependent kinase inhibitor 2A, transcript variant 3 3.14 0.0472
   CDKN2A   1.56 0.4706
19 NM_001274.3 CHEK1 CHK1 checkpoint homolog 3.14 0.0105
20 NM_016426.4 GTSE1 G-2 and S-phase expressed 1 6.69 0.0014
21 NM_182649.1 PCNA1 Proliferating cell nuclear antigen, transcript variant 2 4.66 0.0397
22 NM_006034.2 TP53I11 Tumor protein p53 inducible protein 11 -54.31 2.31E-06
DNA repair     
23 NM_007304.2 BRCA1 Breast cancer 1, transcript variant BRCA1-delta11b 3.70 0.0092
24 NM_007299.2 BRCA1 Breast cancer 1, transcript variant BRCA1-delta14-17 3.06 0.0068
   BRCA1   5.47 0.0037
Immunity and defense     
25 NM_000963.1 PTGS2 Prostaglandin-endoperoxide synthase 2 -15.59 0.0074
Metabolism     
26 NM_201397.1 GPX1 Glutathione peroxidase 1, transcript variant 2 -2.16 0.0011
27 NM_004530.2 MMP2 Metallopeptidase 2 -6.61 0.0296
28 NM_001034.1 RRM21 Ribonucleotide reductase M2 polypeptide 10.48 0.0068
Signal Transduction     
29 NM_000623.2 BDKRB2 Bradykinin receptor B2 -16.54 0.0040
Transport     
30 NM_002539.1 ODC1 Ornithine decarboxylase 1 4.12 0.0099
31 NM_018976.3 SLC38A2 Solute carrier family 38, member 2 -5.03 0.0074
Biological function unclassified    
32 NM_018685.2 ANLN Anillin 8.88 4.17E-06
33 XM_001133677.1 LOC729264 PREDICTED: Similar to TP53TG3 protein, transcript variant 2 25.41 0.0068
34 NM_016212.2 TP53TG3 Tumor protein p53 target gene 3 102.59 0.0005
  1. Fold change in mRNA expression of 34 P53 target genes found to be significantly different in melanoma cell lines (IgR3, Mel-RM, MM200, Me1007, Me4405, Sk-Mel-28) compared to normal cell lines (melanocytes, FLOW2000, HDF1314) (> 2-fold difference, p ≤ 0.05 and FDR = 5.0%). Real-time qRT-PCR verification of selected genes is shown in italics. 1Genes found to be differentially expressed between metastatic melanoma patients and melanocytes.