Table 2 P53 targets differentially expressed in melanoma cells

Apoptosis

Induction of apoptosis

1

NM_138765.2

BAX

BCL2-associated X protein, transcript variant sigma

-4.19

0.0062

2

NM_004324.3

BAX¹

BCL2-associated X protein, transcript variant beta

-4.67

0.0059

3

NM_001225.3

CASP4

Caspase 4, transcript variant alpha

-2.32

0.0027

4

NM_001226.3

CASP6¹

Caspase 6, transcript variant alpha

3.17

0.0401

5

NM_021202.1

TP53INP2

Tumor protein p53 inducible nuclear protein 2

-3.02

0.0034

6

NM_147184.1

TP53I3/PIG3

Tumor protein p53 inducible protein 3, transcript variant 2

-3.67

0.0031

Inhibition of apoptosis

7

NM_138578.1

BCL2L1¹

B-cell CLL/lymphoma 2-like 1, transcript variant 1

-2.95

0.0124

8

NM_003840.3

TNFRSF10D¹

Tumor necrosis factor receptor superfamily, member 10d

-33.80

0.0005

Cell cycle, proliferation and differentiation

9

NM_001012271.1

BIRC5

Baculoviral IAP repeat-containing 5 (Survivin), transcript variant 3

4.60

0.0024

BIRC5

12.61

1.8E-05

10

NM_031966.2

CCNB1

Cyclin B1

18.17

0.0005

11

NM_001759.2

CCND2¹

Cyclin D2

-75.73

0.0427

12

NM_001238.1

CCNE1¹

Cyclin E1, transcript variant 1

2.34

0.0310

13

NM_057735.1

CCNE2

Cyclin E2, transcript variant 2

9.33

0.0198

14

NM_001786.2

CDC2/CDK1

Cell division cycle 2, transcript variant 1

6.32

0.0127

15

NM_001790.3

CDC25C

Cell division cycle 25 homolog C, transcript variant 1

17.05

0.0020

16

NM_001790.3

CDC25C

Cell division cycle 25 homolog C, transcript variant 1

15.26

0.0001

17

NM_022809.2

CDC25C

Cell division cycle 25 homolog C, transcript variant 2

13.39

0.0011

CDC25C

18.21

0.0004

18

NM_058197.3

CDKN2A¹

Cyclin-dependent kinase inhibitor 2A, transcript variant 3

3.14

0.0472

CDKN2A

1.56

0.4706

19

NM_001274.3

CHEK1

CHK1 checkpoint homolog

3.14

0.0105

20

NM_016426.4

GTSE1

G-2 and S-phase expressed 1

6.69

0.0014

21

NM_182649.1

PCNA¹

Proliferating cell nuclear antigen, transcript variant 2

4.66

0.0397

22

NM_006034.2

TP53I11

Tumor protein p53 inducible protein 11

-54.31

2.31E-06

DNA repair

23

NM_007304.2

BRCA1

Breast cancer 1, transcript variant BRCA1-delta11b

3.70

0.0092

24

NM_007299.2

BRCA1

Breast cancer 1, transcript variant BRCA1-delta14-17

3.06

0.0068

BRCA1

5.47

0.0037

Immunity and defense

25

NM_000963.1

PTGS2

Prostaglandin-endoperoxide synthase 2

-15.59

0.0074

Metabolism

26

NM_201397.1

GPX1

Glutathione peroxidase 1, transcript variant 2

-2.16

0.0011

27

NM_004530.2

MMP2

Metallopeptidase 2

-6.61

0.0296

28

NM_001034.1

RRM2¹

Ribonucleotide reductase M2 polypeptide

10.48

0.0068

Signal Transduction

29

NM_000623.2

BDKRB2

Bradykinin receptor B2

-16.54

0.0040

Transport

30

NM_002539.1

ODC1

Ornithine decarboxylase 1

4.12

0.0099

31

NM_018976.3

SLC38A2

Solute carrier family 38, member 2

-5.03

0.0074

Biological function unclassified

32

NM_018685.2

ANLN

Anillin

8.88

4.17E-06

33

XM_001133677.1

LOC729264

PREDICTED: Similar to TP53TG3 protein, transcript variant 2

25.41

0.0068

34

NM_016212.2

TP53TG3

Tumor protein p53 target gene 3

102.59

0.0005