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Table 1 P53 targets differentially expressed in melanoma metastases

From: P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

No. Accession No. Gene Symbol Gene Name Fold change p-value
Apoptosis     
1 NM_001040619.1 ATF3 Activating transcription factor 3, transcript variant 4 4.62 0.0042
2 NM_003879.3 CFLAR/FLIP CASP8 and FADD-like apoptosis regulator 3.10 0.0063
3 NM_004324.3 BAX BCL2-associated X protein, transcript variant beta -3.92 0.0127
4 NM_138578.1 BCL2L1 BCL2-like 1 (Bcl-xL), transcript variant 1 -5.77 0.0144
5 NM_001226.3 CASP6 Caspase 6, transcript variant alpha -13.07 4.98E-05
6 NM_033340.2 CASP7 Caspase 7, transcript variant beta -3.69 0.0465
7 NM_001080125.1 CASP8 Caspase 8, transcript variant G -11.38 2.28E-05
8 NM_033356.3 CASP8 Caspase 8, transcript variant C -2.96 0.0273
9 NM_001007277.1 EI24 Etoposide induced 2.4 mRNA, transcript variant 2 -2.81 0.0245
10 NM_021127.1 PMAIP1 Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa) 12.18 0.0063
11 NM_000314.4 PTEN Phosphatase and tensin homolog -3.29 0.0062
12 NM_003840.3 TNFRSF10D Tumor necrosis factor receptor superfamily, member 10d -29.89 8.37E-07
13 NM_004881.2 TP53I3 Tumor protein p53 inducible protein 3, transcript variant 1 -4.50 0.0097
Cell cycle, proliferation and differentiation   
14 NM_033031.2 CCNB3 Cyclin B3, transcript variant 3 -8.38 1.47E-04
15 NM_033031.2 CCNB3 Cyclin B3, transcript variant 3 -10.79 1.18E-04
16 NM_001759.2 CCND2 Cyclin D2 76.10 1.73E-07
17 NM_001238.1 CCNE1 Cyclin E1, transcript variant 1 -7.61 2.07E-10
18 NM_057749.1 CCNE2 Cyclin E2 3.54 0.0476
19 NM_199246.1 CCNG1 Cyclin G1, transcript variant 2 -5.75 0.0146
20 NM_004354.1 CCNG2 Cyclin G2 -10.66 2.10E-04
21 NM_001798.2 CDK2 Cyclin-dependent kinase 2, transcript variant 1 -4.09 0.0476
22 NM_001798.2 CDK2 Cyclin-dependent kinase 2, transcript variant 1 -17.99 0.0017
23 NM_058197.3 CDKN2A Cyclin-dependent kinase inhibitor 2A, transcript variant 3 4.97 0.0202
24 NM_058195.2 CDKN2A Cyclin-dependent kinase inhibitor 2A, transcript variant 4 -7.09 0.0351
25 NM_015675.2 GADD45B Growth arrest and DNA-damage-inducible, beta 7.41 0.0020
26 NM_006705.2 GADD45G Growth arrest and DNA-damage-inducible, gamma 11.13 0.0154
27 NM_002592.2 PCNA Proliferating cell nuclear antigen, transcript variant 1 -7.25 4.32E-04
28 NM_182649.1 PCNA Proliferating cell nuclear antigen, transcript variant 2 -4.53 0.0219
29 NM_000321.2 RB1 Retinoblastoma 1 -5.85 0.0097
DNA repair     
30 NM_138292.3 ATM Ataxia telangiectasia mutated, transcript variant 2 4.49 0.0328
31 NM_007306.2 BRCA1 Breast cancer 1, early onset, transcript variant BRCA1-exon4 -3.56 0.0371
Immunity and defense     
32 NM_001024844.1 CD82 CD82 molecule, transcript variant 2 -4.80 0.0127
33 NM_002996.3 CX3CL1 Chemokine (C-X3-C motif) ligand 1 9.44 2.67E-05
34 NM_153201.1 HSPA8 Heat shock 70kDa protein 8, transcript variant 2 -3.47 0.0350
35 NM_006597.3 HSPA8 Heat shock 70kDa protein 8, transcript variant 1 -3.31 0.0100
36 NM_001098631.1 IRF5 Interferon regulatory factor 5, transcript variant 7 13.39 3.78E-04
37 NM_182826.1 SCARA3 Scavenger receptor class A, member 3, transcript variant 2 6.60 0.0139
38 NM_003246.2 THBS1 Thrombospondin 1 81.54 1.31E-08
39 NM_003247.2 THBS2 Thrombospondin 2 4.16 0.0408
Metabolism     
40 NM_020128.1 MDM1 Mdm4, transformed 3T3 cell double minute 1, transcript variant 2 -3.98 0.0146
41 NM_020128.1 MDM1 Mdm4, transformed 3T3 cell double minute 1, transcript variant 2 7.64 0.0023
42 NM_004530.2 MMP2 Matrix metallopeptidase 2 -12.58 0.0017
43 NM_000603.3 NOS3 Nitric oxide synthase 3 11.77 4.62E-05
44 NM_033239.2 PML Promyelocytic leukemia, transcript variant 9 -6.24 2.81E-04
45 NM_001034.1 RRM2 Ribonucleotide reductase M2 polypeptide -3.38 0.0476
46 NM_005063.4 SCD Stearoyl-CoA desaturase -4.04 0.0039
Transcription regulation    
47 NM_006210.1 PEG3 Paternally expressed 3 42.85 2.28E-05
48 NM_003068.3 SNAI2/SLUG Snail homolog 2 -27.69 9.45E-07
49 NM_004295.3 TRAF4 TNF receptor-associated factor 4 3.75 0.0033
50 NM_152240.1 ZMAT3/WIG1 Zinc finger, matrin type 3, transcript variant 2 -6.97 0.0024
Signal transduction     
51 NM_014376.2 CYFIP2 Cytoplasmic FMR1 interacting protein 2, transcript variant 3 17.86 1.20E-08
52 NM_004431.2 EPHA2 EPH receptor A2 5.42 0.0031
53 NM_001005914.1 SEMA3B Semaphorin 3B, transcript variant 2 156.75 1.59E-08
Unknown function     
54 NM_012242.2 DKK1 Dickkopf homolog 1 -17.41 0.0097
55 NM_182915.2 STEAP3 STEAP family member 3, transcript variant 1 8.22 0.0024
56 NM_005802.2 TOPORS Topoisomerase I binding, arginine/serine-rich -4.13 0.0350
  1. Fold change in mRNA expression of P53 target genes found to be significantly different in extracts from 82 metastatic melanomas compared to extracts from 8 melanocyte cell lines (> 2-fold difference, p < 0.05 and a false discovery rate (FDR) = 5.0%).