Table 3 Correlation of biomarkers with therapy response
Marker | Time | Response N = 32 | No-Response N = 39 | P-Value |
|---|---|---|---|---|
Nucleosomes (ng/mL) | 0 h | 107.5 | 80.7 | 0.142 |
24 h | 81.8 | 231.1 | 0.002 | |
pc. | -26.2 | 114.3 | < 0.001 | |
AFP (ng/mL) | 0 h | 4.4 | 7.9 | 0.011 |
24 h | 4.2 | 7.9 | 0.010 | |
pc. | 0 | 0 | 0.822 | |
CYFRA 21-1 (ng/mL) | 0 h | 1.8 | 2.0 | 0.349 |
24 h | 2.0 | 2.2 | 0.101 | |
pc. | 0 | 14.3 | 0.229 | |
LDH (U/L) | 0 h | 198.5 | 200.0 | 0.288 |
24 h | 240.0 | 250.0 | 0.746 | |
pc. | 21.6 | 21.0 | 0.712 | |
CRP (mg/dL) | 0 h | 0.4 | 0.8 | 0.424 |
24 h | 1.2 | 1.5 | 0.361 | |
pc. | 100.0 | 133.3 | 0.644 | |
CHE (kU/L) | 0 h | 4.4 | 4.4 | 0.636 |
24 h | 4.6 | 4.4 | 0.652 | |
pc. | 3.0 | 4.6 | 0.514 | |
AST (U/L) | 0 h | 41.5 | 56.0 | 0.084 |
24 h | 101.0 | 89.0 | 0.556 | |
pc. | 102.6 | 50.0 | 0.241 | |
ALT (U/L) | 0 h | 37.5 | 38.0 | 0.652 |
24 h | 63.5 | 57.0 | 0.138 | |
pc. | 72.6 | 19.8 | 0.051 | |
GLDH (U/L) | 0 h | 5.0 | 7.7 | 0.150 |
24 h | 12.7 | 18.4 | 0.922 | |
pc. | 151.7 | 90.0 | 0.280 | |
Bilirubin (mg/dL) | 0 h | 0.9 | 1.0 | 0.276 |
24 h | 1.5 | 1.6 | 0.231 | |
pc. | 47.7 | 60.0 | 0.995 | |
GGT (U/L) | 0 h | 109.0 | 192.0 | 0.034 |
24 h | 108.5 | 206.0 | 0.027 | |
pc. | 2.8 | 5.7 | 0.234 | |
AP (U/L) | 0 h | 119.5 | 140.0 | 0.023 |
24 h | 112.5 | 143.0 | 0.006 | |
pc. | -4.1 | 1.9 | 0.317 |