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Table 3 Measurement of adenine nucleotides in Hepa-1 c4 and WT tumours

From: Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

μmol/g/wet wt

c4

WT

P value

ATP

0.72 ± 0.05

1.03 ± 0.1

<0.03*

ADP

0.57 ± 0.04

0.42 ± 0.04

<0.02*

AMP

0.28 ± 0.05

0.09 ± 0.02

<0.02*

Total AdN

2.07 ± 0.03

2.11 ± 0.08

>0.6

AMP:ATP

0.41 ± 0.11

0.09 ± 0.03

<0.01*

  1. * denotes difference between c4 and WT.
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BMC Cancer

ISSN: 1471-2407

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