Figure 3

Microarray analysis of genes differentially regulated by both TIG1A and TIG1B in HCT116 cells. Control (Ctrl), TIG1A, and TIG1B stable cells were treated with 5 nM MFP for 24 h. Profiles of gene expression were then determined using microarray analysis. After comparing to the gene expression in control cells, genes upregulated or downregulated by greater than two-fold in both TIG1A and TIG1B stable cells were subjected to hierarchical clustering. Average expression was defined by the GeneSpring^® software. The relative scale of upregulation (red) or downregulation (green) of gene expression is shown in the right panel.