From: Influence of family size and birth order on risk of cancer: a population-based study
 |  | Age at diagnosis < 50 years | Age at diagnosis ≥ 50 years | All | ||||||
---|---|---|---|---|---|---|---|---|---|---|
 |  |  | Family size | Ref |  | Family size | Ref |  | Family size | Ref |
Cancer site | (ICD-7 code) | N | RR (95% CI) | N | N | RR (95% CI) | N | N | RR (95% CI) | N |
Upper aero-digestive tract | (140+) | 694 | 1.00 (0.81-1.23) | 104 | 1068 | 0.96 (0.84-1.09) | 316 | 1762 | 0.97 (0.87-1.09) | 420 |
Salivary glands | (142) | 222 | 0.85 (0.62-1.17) | 38 | 117 | 0.87 (0.61-1.24) | 38 | 339 | 0.87 (0.68-1.10) | 76 |
Esophagus | (150) | 85 | 0.52 (0.33-0.82) | 22 | 528 | 0.99 (0.82-1.18) | 155 | 613 | 0.92 (0.77-1.10) | 177 |
Stomach | (151) | 423 | 0.91 (0.68-1.21) | 70 | 1009 | 1.17 (1.02-1.34) | 253 | 1432 | 1.11 (0.96-1.29) | 323 |
Small intestine | (152) | 140 | 0.76 (0.53-1.09) | 29 | 282 | 1.14 (0.91-1.44) | 71 | 422 | 1.03 (0.84-1.27) | 100 |
Colon | (153) | 1633 | 1.01 (0.88-1.17) | 233 | 3213 | 0.95 (0.89-1.02) | 1042 | 4846 | 0.97 (0.91-1.03) | 1275 |
Rectum | (154/1541) | 632 | 1.13 (0.78-1.65) | 87 | 2152 | 0.96 (0.88-1.04) | 672 | 2784 | 0.98 (0.88-1.09) | 759 |
Anus | (1541) | 105 | 0.93 (0.59-1.48) | 17 | 171 | 1.03 (0.75-1.41) | 47 | 276 | 1.01 (0.79-1.30) | 64 |
Liver and gallbladder | (155, 156) | 376 | 1.23 (0.92-1.65) | 43 | 972 | 0.95 (0.83-1.08) | 302 | 1348 | 0.99 (0.88-1.11) | 345 |
Pancreas | (157) | 231 | 1.00 (0.72-1.40) | 31 | 1176 | 0.93 (0.81-1.06) | 369 | 1407 | 0.94 (0.84-1.05) | 400 |
Nose | (160) | 85 | 1.24 (0.58-2.67) | 10 | 95 | 1.53 (0.96-2.44) | 19 | 180 | 1.39 (0.89-2.17) | 29 |
Larynx | (161) | 111 | 1.09 (0.64-1.86) | 18 | 304 | 1.15 (0.91-1.45) | 76 | 415 | 1.15 (0.90-1.47) | 94 |
Lung | (162, 163) | 926 | 1.20 (0.97-1.48) | 117 | 4254 | 0.95 (0.89-1.02) | 1290 | 5180 | 0.99 (0.93-1.05) | 1407 |
Breast | (170) | 8325 | 0.91 (0.70-1.20) | 1506 | 11473 | 0.98 (0.95-1.02) | 3215 | 19798 | 0.96 (0.86-1.08) | 4721 |
Cervix | (171) | 2782 | 0.97 (0.82-1.14) | 424 | 488 | 0.82 (0.69-0.98) | 158 | 3270 | 0.93 (0.82-1.05) | 582 |
Endometrium | (172) | 412 | 0.67 (0.55-0.81) | 122 | 2145 | 0.78 (0.72-0.84) | 821 | 2557 | 0.76 (0.71-0.82) | 943 |
Uterus | (173, 174) | 258 | 1.29 (1.05-1.60) | 33 | 208 | 0.94 (0.77-1.15) | 64 | 466 | 1.07 (0.93-1.24) | 97 |
Ovary | (175) | 1532 | 0.98 (0.84-1.16) | 238 | 1542 | 0.99 (0.89-1.11) | 441 | 3074 | 0.99 (0.90-1.09) | 679 |
Other female genital | (176) | 195 | 1.32 (0.95-1.83) | 23 | 189 | 1.02 (0.76-1.38) | 50 | 384 | 1.14 (0.92-1.40) | 73 |
Prostate | (177) | 144 | 0.85 (0.60-1.21) | 24 | 9489 | 0.98 (0.95-1.01) | 3047 | 9633 | 0.98 (0.95-1.02) | 3071 |
Testis | (178) | 2857 | 0.87 (0.80-0.94) | 393 | 139 | 0.96 (0.75-1.22) | 38 | 2996 | 0.87 (0.81-0.94) | 431 |
Other male genital | (179) | 114 | 1.08 (0.80-1.46) | 17 | 145 | 1.16 (0.91-1.49) | 34 | 259 | 1.14 (0.95-1.36) | 51 |
Kidney | (180) | 1112 | 1.01 (0.86-1.19) | 159 | 1460 | 0.99 (0.88-1.11) | 440 | 2572 | 0.99 (0.91-1.08) | 599 |
Urinary bladder | (181) | 834 | 1.04 (0.88-1.22) | 141 | 2295 | 0.94 (0.87-1.02) | 751 | 3129 | 0.96 (0.89-1.03) | 892 |
Melanoma | (190) | 4919 | 0.85 (0.78-0.93) | 822 | 2740 | 0.96 (0.88-1.04) | 802 | 7659 | 0.90 (0.84-0.96) | 1624 |
Squamous cell skin | (191) | 708 | 0.98 (0.80-1.21) | 109 | 1433 | 0.89 (0.81-0.97) | 514 | 2141 | 0.90 (0.82-0.99) | 623 |
Eye | (192) | 480 | 0.97 (0.75-1.25) | 60 | 181 | 0.96 (0.72-1.28) | 53 | 661 | 0.97 (0.80-1.18) | 113 |
Nervous system | (193) | 6286 | 1.16 (1.05-1.29) | 658 | 2192 | 1.06 (0.96-1.16) | 564 | 8478 | 1.13 (1.05-1.21) | 1222 |
Thyroid gland | (194) | 1496 | 1.00 (0.87-1.14) | 219 | 356 | 1.12 (0.89-1.41) | 89 | 1852 | 1.03 (0.91-1.16) | 308 |
Endocrine glands | (195) | 1718 | 1.00 (0.88-1.14) | 256 | 1189 | 1.00 (0.88-1.13) | 331 | 2907 | 1.01 (0.92-1.10) | 587 |
Bone | (196) | 821 | 1.04 (0.84-1.29) | 91 | 69 | 1.12 (0.71-2.17) | 15 | 890 | 1.08 (0.89-1.31) | 106 |
Connective tissue | (197) | 1013 | 0.96 (0.81-1.14) | 135 | 318 | 0.94 (0.76-1.17) | 97 | 1331 | 0.95 (0.83-1.09) | 232 |
Non-Hodgkin lymphoma | (200, 202) | 2163 | 1.00 (0.85-1.18) | 282 | 2038 | 0.97 (0.88-1.07) | 602 | 4201 | 0.98 (0.90-1.07) | 884 |
Hodgkin lymphoma | (201) | 1736 | 0.94 (0.81-1.09) | 212 | 141 | 0.86 (0.62-1.20) | 44 | 1877 | 0.93 (0.81-1.07) | 256 |
Myeloma | (203) | 211 | 1.32 (0.89-1.94) | 25 | 660 | 0.96 (0.82-1.11) | 207 | 871 | 1.00 (0.87-1.15) | 232 |
Leukaemia | (204 - 209) | 3775 | 1.30 (1.07-1.59) | 343 | 1429 | 1.06 (0.95-1.18) | 397 | 5204 | 1.20 (1.08-1.33) | 740 |
Other and unspecified sites | (other) | 707 | 1.00 (0.81-1.24) | 97 | 1766 | 0.90 (0.80-1.03) | 577 | 2473 | 0.93 (0.84-1.02) | 674 |
Any site | (any) | 50261 | 0.97 (0.94-1.00) | 7208 | 59426 | 0.99 (0.94-1.04) | 18001 | 109687 | 0.99 (0.96-1.02) | 25209 |