Figure 1

Role of CD248 in tumor growth in mice. A. Growth of T241 tumors is significantly reduced in CD248^KO/KO mice (n = 6, p < 0.001). B. Growth of T241 tumors is significantly reduced in CD248^CyD/CyD mice (n = 6, p < 0.001). C. LLC tumors implanted in the cecum are significantly smaller in CD248^CyD/CyD mice (n = 7, p < 0.05). D. PancO2 tumors grown orthotopically are not different in size in CD248^WT/WT and CD248^CyD/CyD mice (n = 4, p = not significant). E. LLC tumor growth in the footpad is similar in CD248^WT/WT and CD248^CyD/CyD mice (n = 6, p = not significant). F-G. Morphometric quantification reveals that there are no genotype-dependent differences in vessel density (F) or PC coverage (G) (n = 7, p = not significant). Data represent the mean ± SEM. Asterisks denote statistical significance.