Table 3 Data mining of AQP4-correlated genes across five independent microarray datasets using commercial pathway database (Ingenuity Pathway Analysis)
From: Loss of aquaporin-4 expression and putative function in non-small cell lung cancer
Relevant Functions and Diseases | No. of genes | Examples (Gene Symbol) |
|---|---|---|
Cancer | 65 | CALCRL, CDC2, CDH5, DMBT1, EZH2, FABP4, FOLR1, ROS1, THBS2 |
Respiratory Disease | 25 | ANGPT1, BUB1B, CAV1, EDNRB, PLK1, RRM1, TGFBR2, TOP2A, VWF |
Cell Cycle | 17 | BUB1B, CDC45L, CDKN3, CENPF, CITED2, MYBL2, PTTG1, RPS6KA2 |
Lipid Metabolism | 15 | CAT, CAV1, CYP27A1, FABP4, LPL, SEPP1, SFTPA1, SFTPB, SFTPC, SFTPD |
Molecular Transport | 17 | ABCA3, AGTR2, AQP1, CFD, CYP27A1 NME1 |
Small Molecule Biochemistry | 30 | A2M, AOC3, C7, CAT, DIO2, GPX3, LPL, NPR1, PFN2, SEPP1, TEK, TK1 |
Cellular Movement | 35 | CAT, CTSE, DLC1, ESAM, ICAM2, PLA2G1B, S1PR1, SFTPC, SFTPD, VIPR1 |
Cell-to-Cell Signalling | 30 | C4BPA, COL4A3, DPYSL2, PTPRB, SLC6A4, SULF1, THY1, TROAP |