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Table 3 Promoter methylation of individual genes in NSCLC - multivariable models assessing PIK3CA amplification, smoking history, histologic type, and lymph node metastasis (OR and 95%CI)

From: Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

Genes PIK3CA amplification Smoking history SSC vs . ADC Lymph node metastasis
CALCA 2.55 (0.81-8.08) 1.08 (0.41-2.84) 1.46 (0.51-4.16) 1.38 (0.44-4.31)
CDH1 0.42 (0.16-1.12) 1.35 (0.52-3.47) 4.01 (1.37-11.79)* 0.64 (0.24-1.75)
DAPK1 0.59 (0.11-3.15) 1.45 (0.39-5.30) 6.09 (1.25-29.66)* 2.26 (0.24-21.44)
EVX2 1.31 (0.47-3.69) 0.94 (0.36-2.43) 2.06 (0.73-5.84) 0.92 (0.32-2.65)
PAX6 0.19 (0.06-0.62)* 0.97 (0.31-3.11) 2.62 (0.68-10.14) 0.62 (0.19-2.05)
RASSF1A 1.63 (0.57-4.70) 0.65 (0.22-1.95) 0.32 (0.09-1.18) 0.67 (0.24-1.87)
  1. † OR: odds ratio with 95% confidence interval, adjusted for multiple comparisions.
  2. * Significant at P < 0.05.