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Table 3 GLM-MANOVA test of the overall effect of the sociodemographic and clinical variables on the EORTC QLQ-C30 and H&N35 scales

From: Health-related Quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires

  QLQ-C30 QLQ-H&N35
  One-factor model* Multifactor model** One-factor model* Multifactor model**
Variable Wilk's λ p Wilk's λ p Wilk's λ p Wilk's λ p
Sociodemographic variables         
Age: <40 v 40~60 v ≥ 60 years 0.922 0.016 0.942 NS 0.926 0.013 0.939 NS
Gender: female v male 0.890 <0.01 0.877 <0.01 0.919 0.018 0.963 NS
Education years: ≤ 6 v 6~12 v >12 0.914 0.011 0.928 NS 0.920 0.033 0.941 NS
Marital status: with v without spouse 0.958 0.042 0.951 NS 0.975 NS 0.968 NS
Annual family income: < 0.6 v 0.6~1.2 v ≥ 1.2 (million NTD) 0.845 <0.01 0.896 0.032 0.866 <0.01 0.910 NS
Clinical variables         
CCI score: 0 v ≥ 1 0.937 0.001 0.910 NS 0.965 NS 0.935 NS
Tumor site: Oral cavity v Oropharynx v Hypopharynx/Larynx v Nasopharynx 0.805 <0.01 0.828 <0.01 0.618 <0.01 0.824 <0.01
AJCC stage: stage I-II v III-IV 0.870 <0.01 0.863 <0.01 0.880 <0.01 0.869 NS
Treatment methods: S + RT v S + RT+ C/T v RT±C/T 0.865 <0.01 0.845 <0.01 0.832 <0.01 0.906 NS
RT technique: 2DRT v 3DCRT v IMRT 0.888 <0.01 0.876 <0.01 0.869 <0.01 0.829 <0.01
Follow-up years: 2~3 v 3~5 v > 5 0.937 NS 0.928 NS 0.933 NS 0.938 NS
  1. *: The one factor model: only one independent variable was entered into the model. **: The multifactor model: all mentioned variables were entered as independent variables in the model. Abbreviations: GLM-MANOVA: general linear model multivariate of variance; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Core questionnaire; H&N35: Head and Neck Module; NTD: New Taiwan Dollar (1 USD = 33 NTD); CCI: Charlson comorbidity index; AJCC: American Joint of Cancer Committee published in 2002; S: surgery; RT: radiotherapy; C/T: chemotherapy; 2DRT: two dimensional RT; 3DCRT: three dimensional conformal RT; IMRT: intensity modulated RT; NS: not significant.