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Table 2 Clinicopathological and lifestyle characteristics of colorectal cancer cases by stratified PTEN expression and PIK3CA mutation status.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

 

PTEN expression status

PIK3CA mutation status

Characteristic

Positive

Negative

P ‡

Wildtype

Mutant

P ‡

 

n = 112†

n = 60†

 

n = 172†

n = 13†

 

Sex

      

   Male

48.2 (54)

46.7 (28)

 

52.0 (90)

23.1 (3)

 

   Female

51.8 (58)

53.3 (32)

0.85

48.0 (83)

76.9 (10)

0.04

Age at diagnosis (years)

71.0 (7.5)

70.0 (8.0)

0.43*

70.3 (7.7)

73.3 (5.6)

0.17*

Tumour location

      

   Proximal colonic

34.0 (35)

42.9 (24)

 

34.4 (55)

53.8 (7)

(FET)

   Distal colonic/Rectal

66.0 (68)

57.1 (32)

0.27

65.6 (105)

46.2 (6)

0.23

Differentiation

      

   Well/Moderate

86.9 (86)

87.0 (47)

 

84.9 (129)

92.3 (12)

(FET)

   Poor

13.1 (15)

13.0 (7.0)

0.98

15.1 (23)

7.7 (1)

0.69

Dukes' Stage

      

   A/B

53.6 (52)

55.8 (29)

 

54.4 (80)

61.5 (8)

 

   C/D

46.4 (45)

44.2 (23)

0.80

45.6 (67)

38.5 (5)

0.62

MSI status

      

   MSS

83.0 (88)

83.3 (45)

 

84.6 (126)

63.6 (7)

(FET)

   MSI

17.0 (18)

16.7 (9)

0.96

15.4 (23)

36.4 (4)

0.09

BMI (kg/m2)

27.3 (4.1)

26.6 (4.4)

0.36*

27.3 (4.3)

25.7 (4.4)

0.20*

Alcohol consumption

9.7 (16)

6.6 (9.7)

0.17*

9.5 (15.0)

5.4 (10)

0.34*

Smoking status

      

   Current

12.0 (13)

8.3 (5)

 

11.2 (19)

0.0 (0)

 

   Former

46.3 (50)

45.0 (27)

 

45.6 (77)

58.3 (7)

 

   Never

41.7 (45)

46.7 (28)

0.69

43.2 (73)

41.7 (5)

0.42

Physical activity

      

   Low

64.3 (72)

70.0 (42)

 

65.7 (113)

84.6 (11)

(FET)

   High

35.7 (40)

30.0 (18)

0.45

34.3 (59)

15.4 (2)

0.23

HRT status

      

   Current

10.3 (6)

6.5 (2)

 

9.8 (8)

0.0 (0)

 

   Former

17.2 (10)

16.1 (5)

 

17.1 (14)

20.0 (2)

 

   Never

72.4 (42)

77.4 (24)

0.81

73.2 (60)

80.0 (8)

0.58

LDL cholesterol (mmol/l)

4.28 (1.2)

3.90 (1.1)

0.05*

4.12 (1.1)

4.30 (1.0)

0.61*

HDL cholesterol (mmol/l)

1.31 (0.4)

1.30 (0.4)

0.96*

1.30 (0.4)

1.29 (0.4)

0.93*

Triglyceride (mmol/l)

1.99 (0.8)

2.25 (1.6)

0.17*

2.09 (1.1)

2.11 (1.5)

0.95*

Plasma vitamin C (μmol/l)

50.3 (18)

53.3 (33)

0.47*

51.2 (24)

54.1 (19)

0.71*

  1. ‡P values determined by χ2 test or Fisher's exact test when one or more expected values were less than 5 (denoted by FET). *: ANOVA tests used to calculate p-values. Results presented as % (n) or mean (±SD). HRT: hormone replacement therapy. MSI: Microsatellite instability. MSS: Microsatellite stable. † Not all individuals had data for each variable, in these cases these individuals were omitted from the test. PTEN expression data were available for 172 cases. For HRT testing only females were analysed.
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BMC Cancer

ISSN: 1471-2407

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