Skip to main content

Table 2 Clinicopathological and lifestyle characteristics of colorectal cancer cases by stratified PTEN expression and PIK3CA mutation status.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

  PTEN expression status PIK3CA mutation status
Characteristic Positive Negative P Wildtype Mutant P
  n = 112 n = 60   n = 172 n = 13  
Sex       
   Male 48.2 (54) 46.7 (28)   52.0 (90) 23.1 (3)  
   Female 51.8 (58) 53.3 (32) 0.85 48.0 (83) 76.9 (10) 0.04
Age at diagnosis (years) 71.0 (7.5) 70.0 (8.0) 0.43* 70.3 (7.7) 73.3 (5.6) 0.17*
Tumour location       
   Proximal colonic 34.0 (35) 42.9 (24)   34.4 (55) 53.8 (7) (FET)
   Distal colonic/Rectal 66.0 (68) 57.1 (32) 0.27 65.6 (105) 46.2 (6) 0.23
Differentiation       
   Well/Moderate 86.9 (86) 87.0 (47)   84.9 (129) 92.3 (12) (FET)
   Poor 13.1 (15) 13.0 (7.0) 0.98 15.1 (23) 7.7 (1) 0.69
Dukes' Stage       
   A/B 53.6 (52) 55.8 (29)   54.4 (80) 61.5 (8)  
   C/D 46.4 (45) 44.2 (23) 0.80 45.6 (67) 38.5 (5) 0.62
MSI status       
   MSS 83.0 (88) 83.3 (45)   84.6 (126) 63.6 (7) (FET)
   MSI 17.0 (18) 16.7 (9) 0.96 15.4 (23) 36.4 (4) 0.09
BMI (kg/m2) 27.3 (4.1) 26.6 (4.4) 0.36* 27.3 (4.3) 25.7 (4.4) 0.20*
Alcohol consumption 9.7 (16) 6.6 (9.7) 0.17* 9.5 (15.0) 5.4 (10) 0.34*
Smoking status       
   Current 12.0 (13) 8.3 (5)   11.2 (19) 0.0 (0)  
   Former 46.3 (50) 45.0 (27)   45.6 (77) 58.3 (7)  
   Never 41.7 (45) 46.7 (28) 0.69 43.2 (73) 41.7 (5) 0.42
Physical activity       
   Low 64.3 (72) 70.0 (42)   65.7 (113) 84.6 (11) (FET)
   High 35.7 (40) 30.0 (18) 0.45 34.3 (59) 15.4 (2) 0.23
HRT status       
   Current 10.3 (6) 6.5 (2)   9.8 (8) 0.0 (0)  
   Former 17.2 (10) 16.1 (5)   17.1 (14) 20.0 (2)  
   Never 72.4 (42) 77.4 (24) 0.81 73.2 (60) 80.0 (8) 0.58
LDL cholesterol (mmol/l) 4.28 (1.2) 3.90 (1.1) 0.05* 4.12 (1.1) 4.30 (1.0) 0.61*
HDL cholesterol (mmol/l) 1.31 (0.4) 1.30 (0.4) 0.96* 1.30 (0.4) 1.29 (0.4) 0.93*
Triglyceride (mmol/l) 1.99 (0.8) 2.25 (1.6) 0.17* 2.09 (1.1) 2.11 (1.5) 0.95*
Plasma vitamin C (μmol/l) 50.3 (18) 53.3 (33) 0.47* 51.2 (24) 54.1 (19) 0.71*
  1. P values determined by χ2 test or Fisher's exact test when one or more expected values were less than 5 (denoted by FET). *: ANOVA tests used to calculate p-values. Results presented as % (n) or mean (±SD). HRT: hormone replacement therapy. MSI: Microsatellite instability. MSS: Microsatellite stable. Not all individuals had data for each variable, in these cases these individuals were omitted from the test. PTEN expression data were available for 172 cases. For HRT testing only females were analysed.