Table 2 Correlations between CAIX expression and clinicopathological factors.
From: Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer
| Carbonic anhydrase IX expression | p-value | |||
|---|---|---|---|---|
| none/weak | moderate/strong | |||
| All samples (n = 221) | 84 | 137 | ||
| Histological subtype (n = 221) | squamous | 53 | 108 | 0.024 |
| adenomatous | 20 | 15 | ||
| adenosquamous | 11 | 14 | ||
| FIGO stage (n = 221) | I | 62 | 74 | 0.013 |
| II | 15 | 46 | ||
| III/IV | 7 | 17 | ||
| UICC tumor stage (n = 221) | pT1 | 65 | 76 | 0.001 |
| pT2 | 15 | 55 | ||
| pT3/4 | 4 | 6 | ||
| Nodal involvement (n = 221) | pN0 | 69 | 99 | 0.106 |
| pN1 | 15 | 38 | ||
| Number of positive lymphnodes (n = 221) | 0 | 69 | 99 | 0.047 |
| 1-3 | 13 | 23 | ||
| >3 | 2 | 15 | ||
| Tumor grade (n = 215) | G1 | 9 | 0 | <0.001 |
| G2 | 32 | 63 | ||
| G3 | 39 | 72 | ||
| Lymphovascular space invasion (n = 196) | L0 | 25 | 39 | 0.875 |
| L1 | 49 | 83 | ||
| Invasion depth in mm (n = 185)* | median | 12 (n = 70) | 16 (n = 115) | 0.025 |
| Patients age in years (n = 221)* | median | 49.5 | 47.0 | 0.549 |
| SCC-Ag in μg/L (n = 144)* | median | 1 (n = 55) | 1.9 (n = 89) | 0.042 |
| Serum CAIX in pg/mL (n = 46)* | median | 91 (n = 17) | 110 (n = 29) | 0.466 |