Skip to main content

Table 3 Cytotoxic activity of the LTX-302, LTX-315 and LTX-318 peptides against lymphoma cell lines expressing different levels of HS.

From: Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells

Cell line

a Cell surface HS

LTX-302 b IC 50 (μM)

LTX-315 IC 50 (μM)

LTX-318 IC 50 (μM)

KMS-5

+

31 ± 0

10 ± 1.5

73 ± 5

U-266

+

36 ± 6

13 ± 1.5

106 ± 17

KMM-1

+

40 ± 6

17 ± 2

111 ± 1

Sudhl-4

-

46 ± 6

23 ± 2

110 ± 5

Ramos

-

30 ± 2

10 ± 1.7

82 ± 11

  1. aCell surface HS was measured using an anti-HS antibody and flow cytometry. Cell lines marked by + express HS, while cell lines marked by - lack HS.
  2. bThe peptide concentration killing 50% of the cells. Data are means of three independent experiments performed in triplicate
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us