Figure 3
From: ABI3 ectopic expression reduces in vitro and in vivocell growth properties while inducing senescence
ABI3 induced p21 WAF1 expression while reducing ERK phosphorylation and E2F1 expression in carcinoma cell lines. (A. two first panels - two upper panels) An increase in p21 WAF1and decrease in E2F1 expression was observed following ABI3 ectopic expression. Black bars correspond to control cells and white bars correspond to ABI3 expressing cells. Graphs show mean ± SD of two clones for each transfectants. (B. third panel-bottom) ABI3 ectopic expression decreases phosphorylated ERK (p-ERK) in WRO cells. Results from two selected clones are show. C1 and C2 (controls clones) and ABI3 1 and ABI3 2 (clones expressing ABI3). α-Tubulin was used as internal control. *p < 0.05.