Table 2 Outcome according to marker status

Total (n = 94)

20%

56%

4.2

(2.8-5.1)

8.6

(5.9-10.4)

KRAS

   Mutation (n = 41)

0%

45%

2.8

(2.2-4.1)

6.5

(4.8-9.8)

   wild type (n = 53)

37%

65%

6.5

(3.5-8.4)

9,9

(6.0-12.2)

p < 0.000

p > 0.05

p = 0.0007

p > 0.05

BRAF

   Mutation (n = 3)

O%

33%

2.1

(1.9-8.5)

4.5

(3.5-25.7)

   Wild type (n = 90)

20%

56%

4.2

(2.8-5.1)

8.6

(5.9-10.4)

p > 0.05

p > 0.05

p > 0.05

p > 0.05

PIK3CA

   Mutation (n = 13)

0%

15%

2.2

(2.1-2.3)

3.5

(3.0-4.7)

   Wild type (n = 81)

23%

63%

4.6

(3.5-6.2)

9.2

(6.6-11.1)

p = 0.053

p = 0.001

p = 0.0003

p = 0.003

PTEN IHC

   Loss of PTEN (n = 13)

8%

46%

3.3

(2.1-6.3)

5.9

(3.6-10.9)

   Normal expression (n = 59)

23%

57%

4.4

(2.8-6.2)

9.2

(6.9-11.1)

p > 0.05

p > 0.05

p > 0.05

p > 0.05

EGFR IHC

   Positive staining (n = 36)

25%

61%

4.3

(2.2-5.7)

9.0

(6.1 -10.9)

   Negative staining (n = 32)

22%

43%

2.8

(2.1-6.9)

8.6

(3.5 - 11.1)

p > 0.05

p > 0.05

p > 0.05

p > 0.05

Triple mutation

   *mutation (n = 49)

0%

40%

2.3

(2.1-3.6)

5.8

(4.5-9.2)

   Negative (n = 45)

41%

73%

7.7

(5.1-8.6)

10.2

(7.1-12.5)

p < 0.0000

p = 0.001

p < 0.000

p > 0.05