| Response | Disease | Median PFS | Median OS | ||
---|---|---|---|---|---|---|
 | Rate | Control Rate | months (95% CI) | months (95% CI) | ||
Total (n = 94) | 20% | 56% | 4.2 | (2.8-5.1) | 8.6 | (5.9-10.4) |
KRAS | Â | Â | Â | Â | Â | Â |
   Mutation (n = 41) | 0% | 45% | 2.8 | (2.2-4.1) | 6.5 | (4.8-9.8) |
   wild type (n = 53) | 37% | 65% | 6.5 | (3.5-8.4) | 9,9 | (6.0-12.2) |
 | p < 0.000 | p > 0.05 | p = 0.0007 | p > 0.05 | ||
BRAF | Â | Â | Â | Â | Â | Â |
   Mutation (n = 3) | O% | 33% | 2.1 | (1.9-8.5) | 4.5 | (3.5-25.7) |
   Wild type (n = 90) | 20% | 56% | 4.2 | (2.8-5.1) | 8.6 | (5.9-10.4) |
 | p > 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | ||
PIK3CA | Â | Â | Â | Â | Â | Â |
   Mutation (n = 13) | 0% | 15% | 2.2 | (2.1-2.3) | 3.5 | (3.0-4.7) |
   Wild type (n = 81) | 23% | 63% | 4.6 | (3.5-6.2) | 9.2 | (6.6-11.1) |
 | p = 0.053 | p = 0.001 | p = 0.0003 | p = 0.003 | ||
PTEN IHC | Â | Â | Â | Â | Â | Â |
   Loss of PTEN (n = 13) | 8% | 46% | 3.3 | (2.1-6.3) | 5.9 | (3.6-10.9) |
   Normal expression (n = 59) | 23% | 57% | 4.4 | (2.8-6.2) | 9.2 | (6.9-11.1) |
 | p > 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | ||
EGFR IHC | Â | Â | Â | Â | Â | Â |
   Positive staining (n = 36) | 25% | 61% | 4.3 | (2.2-5.7) | 9.0 | (6.1 -10.9) |
   Negative staining (n = 32) | 22% | 43% | 2.8 | (2.1-6.9) | 8.6 | (3.5 - 11.1) |
 | p > 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | ||
Triple mutation | Â | Â | Â | Â | Â | Â |
   *mutation (n = 49) | 0% | 40% | 2.3 | (2.1-3.6) | 5.8 | (4.5-9.2) |
   Negative (n = 45) | 41% | 73% | 7.7 | (5.1-8.6) | 10.2 | (7.1-12.5) |
 | p < 0.0000 | p = 0.001 | p < 0.000 | p > 0.05 |