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Table 3 Stratified analysis of associations between APE1/Ref-1 rs1760944 genotypes and risk of all gliomas by age, gender, smoking status, and family history of cancer

From: A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population

Variable

Casesa/Controls (766/824)

Adjusted OR (95% CI)b

 

TT

TG

GG

TG versus TT

GG versus TT

Age (years)

   ≤18

19/15

28/38

9/7

0.58 (0.26-1.32)

1.12

   >18

214/222

364/386

116/148

0.97 (0.77-1.29)

0.80 (0.59-1.10)

Gender

   Male

133/150

233/241

76/92

1.09 (0.81-1.46)

0.63 (0.47-0.85)

   Female

100/87

159/183

49/63

0.72 (0.47-1.09)

0.93 (0.63-1.37)

Smoking status

   Non-smokers

122/140

202/248

61/94

0.91 (0.67-1.25)

0.74 (0.50-1.12)

   Former smokers

23/32

39/66

13/22

0.82 (0.41-1.62)

0.77 (0.32-1.87)

   Current smokers

45/61

93/100

24/37

1.25 (0.77-2.03)

0.87 (0.46-1.67)

Family history of cancer

   No

156/175

250/323

81/119

0.87 (0.66-1.15)

0.76 (0.53-1.10)

   Yes

31/39

80/52

15/23

1.82 (1.01-3.28)

0.82 (0.37-1.83)

  1. aTotal glioma patients including glioblastoma multiform, astrocytomas and other gliomas.
  2. bAdjusted for age and gender.
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BMC Cancer

ISSN: 1471-2407

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