Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

BMC Cancer

Table 6 Relationship between beclin 1 mRNA expression and immunohistochemical characterization of p53, BRCA1 and BRCA2 in breast IDCs

	Case number	Average of log	Standard deviation	P-value
	(%)	T/N	of log T/N
p53
Positive	2 (10)	-0.24	0.24	0.798
Negative	18(90)	-0.20	0.06
BRCA1
Positive	6 (30)	-0.01	0.02	0.014*
Negative	14 (30)	-0.31	0.08
BRCA2
Positive	9 (45)	-0.16	0.04	0.483
Negative	11 (55)	-0.24	0.10

No obvious nuclear p53 protein staining was defined as negative and over-expression of p53 was defined as positive. Loss or reduction of BRCA1 and BRCA2 expression was defined as negative in tumors compared with the paired normal tissue, and vice versa.

ISSN: 1471-2407