Chronological course of the therapy trial. HIT/PT will be administered at least one week after the last chemotherapy cycle on 6 days per week. Chemotherapy prior and after HIT/PT is recommended according to standard therapy protocols and is not part of this trial protocol. After the end of HIT/PT, adjuvant chemotherapy can be continued within one week. Diagnostic investigations have to be done at a specific date pre and after HIT/PT. FDG-PET characteristics will be evaluated prospectively.