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Table 3 Relationship between morphological features, kinetics patterns of enhancement and biological parameters

From: Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Biological Parameters   Morphological features Kinetic features
   Margin Enhancement internal   Peak of maximum enhancement % of maximum enhancement < 2' Curve Type
  N°* A B Hom Het/Rim   < 2' ≥ 2' ≤ 150% > 150% I II III
Total cases 64      68        
Estrogen receptors**              
   Negative 13 3 (23.1) 10 (76.9) 2 (15.4) 11 (84.6) 14 3 (21.4) 11 (78.6) 9 (64.3) 5 (35.7) - 9 (64.3) 5 (35.7)
   Positive 51 13 (25.5) 38 (74.5) 10 (19.6) 41 (80.4) 54 14 (25.9) 40 (74.1) 30 (55.6) 24 (44.4) 5 (9.2) 15 (27.8) 34 (63)
Progesterone receptors**              
   Negative 18 4 (22.2) 14 (77.8) 3 (16.7) 15 (83.3) 20 6 (30) 14 (70) 12 (60) 8 (40) - 9 (45) 11 (55)
   Positive 46 12 (26.1) 34 (73.9) 9 (19.6) 37 (80.4) 48 11 (22.9) 37 (77.1) 27 (56.3) 21 (43.7) 5 (10.4) 15 (31.3) 28 (58.3)
p53**              
   Negative 52 11 (21.2) 41 (78.8) 9 (17.3) 43 (82.7) 56 14 (25) 42 (75) 31 (55.4) 25 (44.6) 5 (8.9) 19 (33.9) 32 (57.2)
   Positive 12 5 (41.7) 7 (58.3) 3 (25) 9 (75) 12 3 (25) 9 (75) 8 (66.7) 4 (33.3) - 5 (41.7) 7 (58.3)
HER2**              
   Negative 38 10 (26.3) 28 (73.7) 8 (21.1) 30 (78.9) 41 9 (22) 32 (78) 23 (56.1) 18 (43.9) 5 (12.2) 15 (36.6) 21 (51.2)
   Positive 26 6 (23.1) 20 (76.9) 4 (15.4) 22 (84.6) 27 8 (29.6) 19 (70.4) 16 (59.3) 11 (40.7) - 9 (33.3) 18 (66.7)
Ki67** 64 17.5
(3-85)
20
(1-95)
17.5
(5-85)
20
(1-95)
68 20
(3-95)
15
(1-85)
20
(1-85)
15
(1-95)
5
(5-45)
15
(1-85)
20
(3-95)
VEGFR-1# 64 59.4
(0-216.1)
54.8
(0-191)
60.7
(0-216.1)
54.2
(0-191)
68 53.6
(0-216.1)
54.7
(0-191)
56.5
(0-216.1)
49.6
(0-139.5)
0
(0-103.4)
50.2
(0-145.8)
56.5
(0-216.1)
VEGFR-2# 64 40.9
(0-126.8)
37.7
(0-155.5)
18.8
(0-155.5)
39.7
(0-140.9)
68 39.2
(0-122.1)
34.1
(0-155.5)
36.2
(0-133.6)
32.8
(0-155.5)
0
(0-56.2)
34
(0-155.5)
39.2
(0-140.9)
  1. * Four cases showed a non-nodular enhancement, so the morphological features were analyzed in only 64 cases, and the kinetic features in all 68 cases.
  2. **Data are expressed as number of cases (percentage).
  3. # Data are expressed as median (range).
  4. Abbreviations: A, well-defined (regular); B, ill-defined (irregular o spiculated); Hom: homogeneous; Het: heterogeneous.