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Table 2 ZIC-like immunoreactivities in brain tumors

From: Expression of ZIC family genes in meningiomas and other brain tumors

 

CXY2

ZC26

ZIC4 nuc_stain*

Grade I Meningioma

++ (12/22)

++ (2/22)

- (22/22)

 

+ (7/22)

+ (14/22)

 
 

± (3/22)

± (6/22)

 

Grade II Meningioma**

++ (1/1)

++ (1/1)

- (1/1)

Grade III Meningioma**

++ (1/1)

+ (1/1)

- (1/1)

Medulloblastoma

++ (4/4)

++ (4/4)

++ (4/4)

Glioblastoma

 

± (1/4)

 
 

- (4/4)

- (3/4)

- (4/4)

Hemangioblastoma

± (2/4)

± (1/4)

 
 

- (2/4)

- (3/4)

- (4/4)

Primitive neuroectodermal tumor

+ (1/1)

+ (1/1)

- (1/1)

Atypical teratoid rhabdoid tumor

+ (1/1)

+ (1/1)

- (1/1)

  1. Intensity of the staining: -, none; ±, low; +, medium; ++, high. *, Although ZIC4 antibodies gave both nuclear and cytoplasmic staining, only the nuclear staining (nuc_stain) were evaluated. **, these two specimens derive from the same patient at different stages.