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Table 2 ZIC-like immunoreactivities in brain tumors

From: Expression of ZIC family genes in meningiomas and other brain tumors

  CXY2 ZC26 ZIC4 nuc_stain*
Grade I Meningioma ++ (12/22) ++ (2/22) - (22/22)
  + (7/22) + (14/22)  
  ± (3/22) ± (6/22)  
Grade II Meningioma** ++ (1/1) ++ (1/1) - (1/1)
Grade III Meningioma** ++ (1/1) + (1/1) - (1/1)
Medulloblastoma ++ (4/4) ++ (4/4) ++ (4/4)
Glioblastoma   ± (1/4)  
  - (4/4) - (3/4) - (4/4)
Hemangioblastoma ± (2/4) ± (1/4)  
  - (2/4) - (3/4) - (4/4)
Primitive neuroectodermal tumor + (1/1) + (1/1) - (1/1)
Atypical teratoid rhabdoid tumor + (1/1) + (1/1) - (1/1)
  1. Intensity of the staining: -, none; ±, low; +, medium; ++, high. *, Although ZIC4 antibodies gave both nuclear and cytoplasmic staining, only the nuclear staining (nuc_stain) were evaluated. **, these two specimens derive from the same patient at different stages.