Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Table 1 Acquired and occurring mutations identified in NAMPT inhibitor resistant cell lines and parental line HCT-116.

The structural position of the mutations has been determined from a published crystal structure of NAMPT [14]. All mutations are located in one allele only. In HCT-116/TP201565 the mutations K342R and Q388R are located on the same allele.

ISSN: 1471-2407