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Table 1 Trials' Characteristics.

From: Impact of hormonal treatment duration in combination with radiotherapy for locally advanced prostate cancer: Meta-analysis of randomized trials

Authors

Pts

Dose RT (Gy)

Arms (mo.)

Median

F.U.

End-Points

Median

PSA (ng/mL)

N° of pts (%)

     

Primary

Secondary

 

Gleason

Score 7-10

T3-T4

Laverdiere et al

148

148

64

5 (AS)

10 (AS)

3.7 yrs

BDFS, CDFS

-

11.9

12.7

82 (27.6)

40 (13.4)

Crook et al

177

184

66

3 (GF)

8 (GF)

79 mo.

OS, CSS, DFS

-

8.9

10.1

178 (49.3)

48 (13.2)

Horwitz et al

763

758

65-70

4 (GF)

24 (GF)

10 yrs

DFS

OS, BF, DMF

20.8

19.8

838 (55.1)

829 (54.5)

Bolla et al

483

487

70

6 (CAB)

36 (CAB)

5.2 yrs

OS, CPFS, DS, BPFS

-

18.8

18.8

479 (49.3)

754 (77.7)

Armstrong et al

127

134

50-74

4 (CAB)

8 (CAB)

102 mo.

BF

OS, CSS

17.0

13.6

153 (55.4)

159 (57.6)

  1. Pts: patients; RT: radiotherapy; Gy: gray; mo.: months; F.U.: follow-up; PSA: serum prostate-specific antigen; N°: number; AS: androgen suppression; yrs: years; BDFS: biochemical disease free survival; CDFS: clinical disease free survival; GF: goserelin + flutamide; OS: overall survival; CSS: cancer specific survival; DFS: disease free survival; BF: biochemical failure; DMF: distant metastases failure; CAB: complete androgen blockade; CPFS: clinical progression free survival; BPFS: biochemical progression free survival: BF: biochemical failure.