Influence of steroid hormone signaling in PC3-AKR1C3 transfectants. (A) Genes whose expression is altered in PC3-AKR1C3 transfectants were identified to be regulated by 17β-estradiol, androstenediol, or 5α-DHT. Genes that are labeled in red and green represent up- and down-regulated genes, respectively, in PC3-AKR1C3 transfectants as compared to PC3-mock transfectants. The fold changes are reflected by corresponding numbers under the gene names. (B) FST expression can be regulated by AKR1C3-mediated testosterone and/or progesterone metabolism in PC3-AKR1C3 transfectants. The legend for the gene shapes is at lower right corner.