NKI ID
|
deleterious TP53 mutation by prediction
|
complex/truncatingTP53 mutation
|
hotspot mutation
|
TP53 IHC
|
ER IHC
|
PR IHC
|
HER2 IHC
|
CK5/6IHC
|
breast cancer subtype/BRCA1 mutation
|
Age at diagnosis
|
---|
BRCA1-mutated breast tumors
| | | | | | | | | |
---|
B107
|
G266E
|
0
|
1
|
0
|
0
|
0
|
0
|
NA
|
c.1319delT
|
41
|
B109
|
R213X, H214Y
|
1
|
1
|
0
|
0
|
0
|
0
|
NA
|
c.IVS21-36del510
|
30
|
B116
|
Y163C
|
0
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.185delAG
|
49
|
B118
|
NA
|
NA
|
NA
|
0
|
0
|
0
|
0
|
NA
|
c.4416_4417delTTinsG
|
34
|
B119
|
NA
|
NA
|
NA
|
0
|
0
|
0
|
0
|
NA
|
c.4416_4417delTTinsG
|
34
|
B122
|
239 insT
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.4446C > T
|
45
|
B124
|
NA
|
NA
|
NA
|
1
|
0
|
0
|
0
|
NA
|
c.3875del4
|
61
|
B125
|
NA
|
NA
|
NA
|
0
|
0
|
0
|
0
|
NA
|
c.2804delAA
|
35
|
B126
|
del 255
|
1
|
0
|
1
|
0
|
0
|
0
|
NA
|
c.IVS21-36del510
|
40
|
B127
|
T55I
|
0
|
0
|
1
|
0
|
0
|
0
|
NA
|
c.5382insC
|
39
|
B135
|
wild type
|
0
|
0
|
1
|
0
|
0
|
0
|
NA
|
c.2312del5
|
41
|
B137
|
224 splice G > A
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.IVS12-1632del3835
|
32
|
B141
|
wild type
|
0
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.IVS21-36del510
|
39
|
B145
|
110 delC, Q100X
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.185delAG
|
33
|
B146
|
145 delG, Q104X, P98S
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.185delAG
|
33
|
B149
|
R273H
|
0
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.IVS20+1G > A
|
31
|
B150
|
V216 M, P223 S, R290C
|
0
|
1
|
0
|
0
|
0
|
0
|
NA
|
c.IVS21-36del510
|
41
|
B152
|
R175H
|
0
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.IVS13+4123ins6081
|
47
|
B153
|
del 155-156
|
1
|
0
|
1
|
0
|
0
|
0
|
NA
|
c.185delAG
|
48
|
B156
|
R248W, R280K, V218I
|
0
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.5382insC
|
47
|
B158
|
R282G, E326K
|
0
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.IVS21-36del510
|
27
|
B160
|
167 insA
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.IVS20+1G > A
|
61
|
B161
|
R213X, R282W, P151R
|
1
|
1
|
1
|
0
|
0
|
0
|
NA
|
c.IVS13+4123ins6081
|
30
|
B162
|
NA
|
NA
|
NA
|
0
|
0
|
0
|
0
|
NA
|
c.IVS20+1G > A
|
27
|
B164
|
258 delG
|
1
|
0
|
0
|
0
|
0
|
0
|
NA
|
c.del exons 1A-7
|
31
|
B165
|
NA
|
NA
|
NA
|
1
|
0
|
0
|
0
|
NA
|
c.IVS12-1632del3835
|
33
|
B171
|
R306X
|
1
|
0
|
0
|
0
|
0
|
1
|
NA
|
c.IVS2-9C > G
|
33
|
Luminal-J breast tumors
| | | | | | | | | |
C002
|
R248W, R110C, T55I
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
Luminal A
|
45
|
C010
|
NA
|
NA
|
NA
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
40
|
C017
|
K305X
|
1
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
36
|
C020
|
wild type
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
Luminal A
|
34
|
C022
|
NA
|
NA
|
NA
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
51
|
C025
|
P177L
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
50
|
C027
|
NA
|
NA
|
NA
|
0
|
1
|
1
|
1
|
0
|
Luminal A
|
45
|
C028
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
41
|
C030
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
38
|
C034
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
47
|
C036
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
40
|
C037
|
NA
|
NA
|
NA
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
49
|
C042
|
P190L
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
42
|
C044
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
45
|
C052
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
45
|
C057
|
P98L
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Luminal B
|
51
|
C060
|
H179R, T125M
|
0
|
1
|
1
|
1
|
1
|
0
|
0
|
Luminal B
|
47
|
Basal-like breast tumors
| | | | | | | | | |
131
|
239_240delCA
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
39
|
135
|
C242Y
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
45
|
164
|
W53X
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
50
|
184
|
183_184insC
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
44
|
215
|
110delC
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
49
|
228
|
IVS5-2 A > C (splice)
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
Basal-like
|
39
|
230
|
E221X
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
Basal-like
|
28
|
238
|
V173M
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
42
|
241
|
R196X
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
41
|
268
|
L252P
|
0
|
0
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
38
|
269
|
N131S
|
0
|
0
|
0
|
0
|
1
|
0
|
1
|
Basal-like
|
38
|
270
|
283insGC
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
50
|
307
|
218delGTG
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
44
|
324
|
I195T
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
46
|
326
|
155_156del
|
1
|
0
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
39
|
330
|
201delT
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
Basal-like
|
26
|
332
|
Q286K
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
49
|
335
|
R248W
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
48
|
367
|
wild type
|
0
|
0
|
1
|
1
|
0
|
1
|
0
|
Basal-like
|
49
|
377
|
255_256delTCA
|
1
|
0
|
1
|
1
|
1
|
0
|
1
|
Basal-like
|
52
|
398
|
Y220C
|
0
|
1
|
1
|
0
|
0
|
0
|
1
|
Basal-like
|
34
|
Luminal-H breast tumors
| | | | | | | | | |
6
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
49
|
107
|
Q317X
|
1
|
0
|
0
|
1
|
1
|
0
|
NA
|
Luminal B
|
38
|
110
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
51
|
145
|
R273C
|
0
|
1
|
0
|
0
|
1
|
0
|
0
|
Luminal B
|
48
|
157 (C002)*
|
R248W
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
Luminal A
|
45
|
166
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
43
|
167
|
wild type
|
0
|
0
|
0
|
1
|
1
|
1
|
0
|
Luminal A
|
44
|
176
|
wild type
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
Luminal A
|
46
|
203
|
wild type
|
0
|
0
|
0
|
1
|
1
|
1
|
0
|
Luminal A
|
49
|
205
|
K132R
|
0
|
1
|
0
|
1
|
1
|
0
|
1
|
Luminal A
|
50
|
214
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
41
|
220
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
42
|
231
|
wild type
|
0
|
0
|
0
|
1
|
1
|
NA
|
0
|
Luminal A
|
43
|
240 (C060)*
|
H179R
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
47
|
295
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
48
|
298
|
wild type
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
Luminal A
|
50
|
302 (C034)*
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
47
|
305 (C036)*
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
40
|
312
|
205delT
|
1
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
47
|
318
|
R110L, S127C
|
0
|
1
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
37
|
322 (C044)*
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
45
|
329
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
49
|
346
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
49
|
354
|
P177R
|
0
|
1
|
1
|
1
|
1
|
0
|
1
|
Luminal A
|
47
|
356
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
49
|
361
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal A
|
42
|
371
|
wild type
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
Luminal A
|
51
|
378
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
52
|
389 (C057)*
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal B
|
51
|
391
|
wild type
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
Luminal A
|
51
|
393
|
wild type
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
Luminal B
|
51
|
- TP53 mutations Bold: predicted truncating TP53 mutation (frameshift, splice, nonsense and in-frame insertions or deletions), plain text: hotspot mutations according to Walker et al. Italics, missense TP53 mutations predicted deleterious by the SIFT or EffectGroup3 algorithms. Immunohistochemistry data for TP53, ER, PR, HER2 and CK5/6; BRCA1-mutation; tumor type as determined by expression profiling; age at diagnosis.
- *The TP53 gene of the BRCA1-mutated, Luminal-J tumors were sequenced in a different laboratory than the BLBCs and the luminal-H tumors. Of the 6 overlapping tumors between Luminal-H and Luminal-J tumors a discrepancy occurs in 3 tumors: In luminal-H tumor 157 a R248W mutation is found and in corresponding Luminal-J tumor C002 an additional R110C and T55I mutations are found. In luminal-J tumor C057 a P98L mutation is found and corresponding luminal-H tumor 389 no mutations are found. In luminal-H tumor 240 a H179R mutation is detected and in corresponding luminal-J tumor C060 an additional T125 M mutation is found.