Table 1 Tumor characteristics of BRCA1-related, Luminal-J, basal-like and Luminal-H breast tumors.
NKI ID | deleterious TP53 mutation by prediction | complex/truncatingTP53 mutation | hotspot mutation | TP53 IHC | ER IHC | PR IHC | HER2 IHC | CK5/6IHC | breast cancer subtype/BRCA1 mutation | Age at diagnosis |
|---|---|---|---|---|---|---|---|---|---|---|
BRCA1-mutated breast tumors | ||||||||||
B107 | G266E | 0 | 1 | 0 | 0 | 0 | 0 | NA | c.1319delT | 41 |
B109 | R213X, H214Y | 1 | 1 | 0 | 0 | 0 | 0 | NA | c.IVS21-36del510 | 30 |
B116 | Y163C | 0 | 1 | 1 | 0 | 0 | 0 | NA | c.185delAG | 49 |
B118 | NA | NA | NA | 0 | 0 | 0 | 0 | NA | c.4416_4417delTTinsG | 34 |
B119 | NA | NA | NA | 0 | 0 | 0 | 0 | NA | c.4416_4417delTTinsG | 34 |
B122 | 239 insT | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.4446C > T | 45 |
B124 | NA | NA | NA | 1 | 0 | 0 | 0 | NA | c.3875del4 | 61 |
B125 | NA | NA | NA | 0 | 0 | 0 | 0 | NA | c.2804delAA | 35 |
B126 | del 255 | 1 | 0 | 1 | 0 | 0 | 0 | NA | c.IVS21-36del510 | 40 |
B127 | T55I | 0 | 0 | 1 | 0 | 0 | 0 | NA | c.5382insC | 39 |
B135 | wild type | 0 | 0 | 1 | 0 | 0 | 0 | NA | c.2312del5 | 41 |
B137 | 224 splice G > A | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.IVS12-1632del3835 | 32 |
B141 | wild type | 0 | 0 | 0 | 0 | 0 | 0 | NA | c.IVS21-36del510 | 39 |
B145 | 110 delC, Q100X | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.185delAG | 33 |
B146 | 145 delG, Q104X, P98S | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.185delAG | 33 |
B149 | R273H | 0 | 1 | 1 | 0 | 0 | 0 | NA | c.IVS20+1G > A | 31 |
B150 | V216 M, P223 S, R290C | 0 | 1 | 0 | 0 | 0 | 0 | NA | c.IVS21-36del510 | 41 |
B152 | R175H | 0 | 1 | 1 | 0 | 0 | 0 | NA | c.IVS13+4123ins6081 | 47 |
B153 | del 155-156 | 1 | 0 | 1 | 0 | 0 | 0 | NA | c.185delAG | 48 |
B156 | R248W, R280K, V218I | 0 | 1 | 1 | 0 | 0 | 0 | NA | c.5382insC | 47 |
B158 | R282G, E326K | 0 | 1 | 1 | 0 | 0 | 0 | NA | c.IVS21-36del510 | 27 |
B160 | 167 insA | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.IVS20+1G > A | 61 |
B161 | R213X, R282W, P151R | 1 | 1 | 1 | 0 | 0 | 0 | NA | c.IVS13+4123ins6081 | 30 |
B162 | NA | NA | NA | 0 | 0 | 0 | 0 | NA | c.IVS20+1G > A | 27 |
B164 | 258 delG | 1 | 0 | 0 | 0 | 0 | 0 | NA | c.del exons 1A-7 | 31 |
B165 | NA | NA | NA | 1 | 0 | 0 | 0 | NA | c.IVS12-1632del3835 | 33 |
B171 | R306X | 1 | 0 | 0 | 0 | 0 | 1 | NA | c.IVS2-9C > G | 33 |
Luminal-J breast tumors | ||||||||||
C002 | R248W, R110C, T55I | 0 | 1 | 0 | 0 | 0 | 1 | 0 | Luminal A | 45 |
C010 | NA | NA | NA | 0 | 1 | 1 | 0 | 0 | Luminal A | 40 |
C017 | K305X | 1 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 36 |
C020 | wild type | 0 | 0 | 1 | 0 | 0 | 0 | 1 | Luminal A | 34 |
C022 | NA | NA | NA | 0 | 1 | 0 | 0 | 0 | Luminal B | 51 |
C025 | P177L | 0 | 1 | 0 | 1 | 1 | 0 | 0 | Luminal A | 50 |
C027 | NA | NA | NA | 0 | 1 | 1 | 1 | 0 | Luminal A | 45 |
C028 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 41 |
C030 | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 38 |
C034 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 47 |
C036 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 40 |
C037 | NA | NA | NA | 0 | 1 | 1 | 0 | 0 | Luminal B | 49 |
C042 | P190L | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 42 |
C044 | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 45 |
C052 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 45 |
C057 | P98L | 0 | 0 | 0 | 0 | 0 | 0 | 0 | Luminal B | 51 |
C060 | H179R, T125M | 0 | 1 | 1 | 1 | 1 | 0 | 0 | Luminal B | 47 |
Basal-like breast tumors | ||||||||||
131 | 239_240delCA | 1 | 0 | 1 | 0 | 0 | 0 | 1 | Basal-like | 39 |
135 | C242Y | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 45 |
164 | W53X | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 50 |
184 | 183_184insC | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 44 |
215 | 110delC | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 49 |
228 | IVS5-2 A > C (splice) | 1 | 0 | 0 | 0 | 0 | 0 | 0 | Basal-like | 39 |
230 | E221X | 1 | 0 | 0 | 0 | 0 | 1 | 0 | Basal-like | 28 |
238 | V173M | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 42 |
241 | R196X | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 41 |
268 | L252P | 0 | 0 | 1 | 0 | 0 | 0 | 1 | Basal-like | 38 |
269 | N131S | 0 | 0 | 0 | 0 | 1 | 0 | 1 | Basal-like | 38 |
270 | 283insGC | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 50 |
307 | 218delGTG | 1 | 0 | 1 | 0 | 0 | 0 | 1 | Basal-like | 44 |
324 | I195T | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 46 |
326 | 155_156del | 1 | 0 | 1 | 0 | 0 | 0 | 1 | Basal-like | 39 |
330 | 201delT | 1 | 0 | 0 | 0 | 0 | 0 | 1 | Basal-like | 26 |
332 | Q286K | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 49 |
335 | R248W | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 48 |
367 | wild type | 0 | 0 | 1 | 1 | 0 | 1 | 0 | Basal-like | 49 |
377 | 255_256delTCA | 1 | 0 | 1 | 1 | 1 | 0 | 1 | Basal-like | 52 |
398 | Y220C | 0 | 1 | 1 | 0 | 0 | 0 | 1 | Basal-like | 34 |
Luminal-H breast tumors | ||||||||||
6 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 49 |
107 | Q317X | 1 | 0 | 0 | 1 | 1 | 0 | NA | Luminal B | 38 |
110 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 51 |
145 | R273C | 0 | 1 | 0 | 0 | 1 | 0 | 0 | Luminal B | 48 |
157 (C002)* | R248W | 0 | 1 | 0 | 0 | 0 | 1 | 0 | Luminal A | 45 |
166 | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 43 |
167 | wild type | 0 | 0 | 0 | 1 | 1 | 1 | 0 | Luminal A | 44 |
176 | wild type | 0 | 0 | 0 | 0 | 1 | 0 | 0 | Luminal A | 46 |
203 | wild type | 0 | 0 | 0 | 1 | 1 | 1 | 0 | Luminal A | 49 |
205 | K132R | 0 | 1 | 0 | 1 | 1 | 0 | 1 | Luminal A | 50 |
214 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 41 |
220 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 42 |
231 | wild type | 0 | 0 | 0 | 1 | 1 | NA | 0 | Luminal A | 43 |
240 (C060)* | H179R | 0 | 1 | 0 | 1 | 1 | 0 | 0 | Luminal B | 47 |
295 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 48 |
298 | wild type | 0 | 0 | 1 | 1 | 1 | 0 | 0 | Luminal A | 50 |
302 (C034)* | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 47 |
305 (C036)* | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 40 |
312 | 205delT | 1 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 47 |
318 | R110L, S127C | 0 | 1 | 0 | 1 | 1 | 0 | 0 | Luminal A | 37 |
322 (C044)* | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 45 |
329 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 49 |
346 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 49 |
354 | P177R | 0 | 1 | 1 | 1 | 1 | 0 | 1 | Luminal A | 47 |
356 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 49 |
361 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal A | 42 |
371 | wild type | 0 | 0 | 1 | 1 | 0 | 0 | 0 | Luminal A | 51 |
378 | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 52 |
389 (C057)* | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal B | 51 |
391 | wild type | 0 | 0 | 0 | 1 | 0 | 0 | 0 | Luminal A | 51 |
393 | wild type | 0 | 0 | 0 | 1 | 1 | 0 | 0 | Luminal B | 51 |